中国医院用药评价与分析2025，Vol.25Issue(4)：416-419,424,5.DOI:10.14009/j.issn.1672-2124.2025.04.008
中医药治疗郁证的用药规律研究
Medication Rules of Traditional Chinese Medicine in the Treatment of Depression Syndrome
摘要
Abstract
OBJECTIVE:To probe into the medication rules of traditional Chinese medicine(TCM)in the treatment of depression syndrome(DS).METHODS:The HIS system was used to export the TCM prescriptions of outpatients with depression syndrome in the hospital from Oct.2021 to Oct.2023,and the real-world data were processed,mined and analyzed by Excel 2019,SPSS Modeler 18.0,SPSS Statistics 27.0 and other software.RESULTS:A total of 5 870 cases were enrolled,of which female patients accounted for 67.94%(3 988 cases).The age of patients was mainly from 11 to 60 years old,especially in the age group of>20 to 30 years.The top 10 types of syndromes in the ranking involved a total of 6 539 cases,heart-kidney disorders(2 614 times,39.98%),liver-Qi stagnation(1 788 times,27.34%)and heart-spleen deficiency(513 times,7.85%)were the common syndrome.The drugs were mainly sweet and bitter in flavor,cold and warm in property,and were mainly attributed to the spleen,lungs,liver and heart.TCM with high-frequency included 20 categories such as Radix bupleuri,Rhizoma pinellinae praeparata,Radix liquiritiae,Codonopsis radix and Ossa draconis.According to the efficacy,TCM with high-frequency were mainly deficiency-supplementing and heat-clearing drugs.The association rules with a high level of confidence coefficient were Radix bupleuri-Rhizoma pinellinae praeparata,Radix bupleuri-Ossa draconis,Chuanxiong rhizoma-Cyperi rhizoma-radix bupleuri,and Cyperi rhizoma-Poria-Radix bupleuri.TCM with high-frequency were clustered into three classes by clustering analysis,and the factor analysis extracted six effective common factors.CONCLUSIONS:Through real-world data mining,the core TCM in the treatment of DS are clarified,and some potential antidepressant drug groups are identified,which provides reference for the prescription selection and medication.关键词
郁证/用药规律/中医药/真实世界Key words
Depression syndrome/Medication rule/Traditional Chinese medicine/Real world分类
药学引用本文复制引用
陈佳美,张子龙,曹丽萍,李方园,唐志芳,潘雅楠,梅全喜,梁奇..中医药治疗郁证的用药规律研究[J].中国医院用药评价与分析,2025,25(4):416-419,424,5.基金项目
广东省自然科学基金-粤深联合基金-青年基金项目(No.2023A1515110376) （No.2023A1515110376）
深圳市"医疗卫生三名工程"项目(No.SZZYSM202206005) （No.SZZYSM202206005）
深圳市中药特色技术传承人才培训项目 （）
