中国医院用药评价与分析2025，Vol.25Issue(4)：420-424,5.DOI:10.14009/j.issn.1672-2124.2025.04.009
扶正消癥汤联合吡柔比星对非肌层浸润性膀胱癌患者术后免疫功能、增殖侵袭基因表达的影响
Effects of Fuzheng Xiaozheng Decoction Combined with Pirarubicin on Postoperative Immune Function,Proliferation and Invasion Gene Expression in Patients with Non-Muscular Invasive Bladder Cancer
摘要
Abstract
OBJECTIVE:To probe into the effects of Fuzheng Xiaozheng decoction combined with pirarubicin on postoperative immune function,proliferation and invasion gene expression in patients with non-muscular invasive bladder cancer(NMIBC).METHODS:A total of 128 patients with NMIBC undergoing surgical treatment in the hospital from Jun.2022 to Oct.2023 were extracted to be divided into two groups according to the random number table method,with 64 cases in each group.The control group was given pirarubicin after surgery,while the observation group received Fuzheng Xiaozheng decoction combined with pirarubicin after surgery.The efficacy,traditional Chinese medicine syndrome score,tumor related factors[serum carbohydrate antigen 125(CA125),matrix metalloproteinase-9(MMP-9),fibroblast growth factor(FGF),vascular endothelial growth factor(VEGF)],immune function(CD3+,CD4+,CD4+/CD8+),proliferative and invasive gene expression[nuclear factor-κB p65(NF-κB p65),integrin-associated kinase(ILK),adenosine triphosphate binding box transporter E1(ABCE1),peroxysomal proliferator-activated receptor(PPARγ)],adverse drug reactions were compared between two groups.RESULTS:The total effective rate of observation group was 89.06%(57/64),higher than 75.00%(48/64)of control group,with statistically significant differences(P<0.05).After treatment,the scores of hematuria,abdominal pain,fatigue and dysuria in observation group were lower than those in control group,MMP-9,VEGF,CA125,FGF,NF-κB p65 mRNA,ILK mRNA and ABCE1 mRNA in observation group were lower than those in control group,and PPARγ mRNA in observation group was higher than that in control group,with statistically significant differences(P<0.05).After treatment,CD3+,CD4+,CD4+/CD8+in the observation group were higher than those before treatment and the control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions in observation group was 7.81%(5/64),lower than 25.00%(16/64)in the control group,with statistically significant differences(P<0.05).CONCLUSIONS:The efficacy of Fuzheng Xiaozheng decoction combined with pirarubicin is significant in the treatment of NMIBC,which can effectively alleviate clinical symptoms,improve postoperative immune function,inhibit tumor angiogenesis and cancer cell invasion and proliferation,and reduce the incidence of adverse drug reactions.关键词
非肌层浸润性膀胱癌/扶正消癥汤/免疫功能/增殖侵袭基因/吡柔比星Key words
Non-muscular invasive bladder cancer/Fuzheng Xiaozheng decoction/Immune function/Proliferation and invasion gene/Pirarubicin分类
药学引用本文复制引用
余翥,余明主,郑慧杰,陈亚梅,高石亮,余春艳,谭公祥..扶正消癥汤联合吡柔比星对非肌层浸润性膀胱癌患者术后免疫功能、增殖侵袭基因表达的影响[J].中国医院用药评价与分析,2025,25(4):420-424,5.基金项目
江西省卫生健康委科技计划项目(No.20221006) （No.20221006）
