中国中医药信息杂志2025，Vol.32Issue(4)：157-162,6.DOI:10.19879/j.cnki.1005-5304.202410394
参元益气活血胶囊治疗稳定性心绞痛合并室性早搏临床研究
Clinical Study on Shenyuan Yiqi Huoxue Capsules for the Treatment of Stable Angina Pectoris with Ventricular Premature Beat
摘要
Abstract
Objective To observe the clinical efficacy of Shenyuan Yiqi Huoxue Capsules for the treatment of stable angina pectoris combined with ventricular premature beat.Methods Totally 70 patients with stable angina pectoris combined with ventricular premature beat were selected,and were divided into control group and experimental group using random number table method,with 35 cases in each group.The control group was given metoprolol tartrate tablets,25 mg/time,twice a day,orally on the basis of conventional Western medicine treatment;the experimental group was treated with Shenyuan Yiqi Huoxue Capsules on the basis of control group treatment,400 mg each time,three times a day.The course of treatment for both groups was three months.The frequency and efficacy of 24 hour ventricular premature beats,TCM syndrome scores and efficacy,heart rate variability(HRV),Seattle Angina Questionnaire(SAQ)score were observed in the two groups before and after treatment.Adverse reactions of both group were monitored.Results The experimental group shed 2 cases,and the control group shed 1 case.The total effective rate of premature ventricular contractions in the experimental group was 96.97%(32/33),while in the control group it was 82.44%(28/34).The experimental group was higher than the control group(P<0.05);the total effective rate of TCM syndrome in the experimental group was 93.94%(31/33),while in the control group it was 73.53%(25/34).The experimental group was higher than the control group(P<0.05).Compared with before treatment,the number of 24 hour ventricular premature beats in both groups decreased significantly after treatment(P<0.01).After treatment,the experimental group had significantly lower 24 hour ventricular premature beats compared to the control group(P<0.05).Compared with before treatment,both groups showed significant increases in HRV indicators and SAQ scores after treatment(P<0.01);after treatment,the HRV indicators and SAQ scores in the experimental group were significantly higher than those in the control group(P<0.05).Compared with before treatment,the TCM syndrome scores of palpitations,chest tightness,shortness of breath,fatigue,spontaneous sweating and insomnia in both groups were significantly reduced after treatment(P<0.01).After treatment,the experimental group had significantly lower TCM symptoms scores such as palpitations,chest tightness,shortness of breath,fatigue,spontaneous sweating and insomnia(P<0.05).There were no adverse reactions in either group.Conclusion Shenyuan Yiqi Huoxue Capsules have a clear effect on the treatment of stable angina pectoris combined with ventricular premature beat,which can reduce the frequency of 24 hour ventricular premature beats,relieve TCM symptoms,improve HRV,and increase the score of SAQ without clinical adverse reactions.关键词
室性早搏/参元益气活血胶囊/气虚血瘀证/心率变异性Key words
ventricular premature beat/Shenyuan Yiqi Huoxue Capsules/qi deficiency and blood stasis syndrome/heart rate variability分类
医药卫生引用本文复制引用
谢皛,戴梅,张竹华..参元益气活血胶囊治疗稳定性心绞痛合并室性早搏临床研究[J].中国中医药信息杂志,2025,32(4):157-162,6.基金项目
北京市医院管理局培育计划(PZ2022023) （PZ2022023）
