中国医院用药评价与分析2025，Vol.25Issue(4)：434-437,441,5.DOI:10.14009/j.issn.1672-2124.2025.04.012
替加环素联合多巴酚丁胺治疗重症肺炎的疗效及对肺功能、免疫功能的影响
Efficacy of Tigecycline Combined with Dobutamine in the Treatment of Severe Pneumonia and Its Effects on Pulmonary Function and Immune Function
摘要
Abstract
OBJECTIVE:To probe into the efficacy of tigecycline combined with dobutamine in the treatment of severe pneumonia and its effects on pulmonary function and immune function.METHODS:A total of 112 patients with severe pneumonia admitted into Zhangjiakou First Hospital from Oct.2021 to Oct.2023 were extracted to be divided into tigacycline group and dobutamine group according to different treatment methods,with 56 cases in each group.The tigacycline group was given tigecycline alone,while the dobutamine group received dobutamine based on the tigacycline group,both groups were treated for 20 d.The levels of immune function indicators,the clinical treatment effects,incidences adverse drug reactions,inflammatory factors,and pulmonary function indicators before and after treatment were recorded and compared between two groups.RESULTS:The total effective rate of the dobutamine group was significantly higher than that of the tigacycline group(94.64%vs.76.79%),with statistically significant difference(χ2=7.292,P<0.05).After treatment,the procalcitonin,C-reactive protein,white blood cell count,central venous pressure,left ventricular end-diastolic volume and CD8+in both groups were significantly lower than those before treatment,the stroke volume,mean arterial pressure,CD4+,CD3+and CD4+/CD8+were significantly higher than those before treatment,and all the above indicators were significantly better in the dobutamine group than those in the tigacycline group,with statistically significant differences(P<0.05).During treatment,the incidence of adverse drug reactions of the dobutamine group was significantly lower than that of the tigacycline group(8.93%vs.25.00%),with statistically significant difference(χ2=3.998,P<0.05).CONCLUSIONS:Compared with tigecycline alone,the combination of tigecycline and dobutamine in the treatment of severe pneumonia can effectively enhance patients'pulmonary function,promote immune function and efficacy.关键词
重症肺炎/多巴酚丁胺/替加环素/免疫功能Key words
Severe pneumonia/Dobutamine/Tigecycline/Immune function分类
医药卫生引用本文复制引用
魏晓颖,王蕊,史玉洁,李霞,张鸿儒..替加环素联合多巴酚丁胺治疗重症肺炎的疗效及对肺功能、免疫功能的影响[J].中国医院用药评价与分析,2025,25(4):434-437,441,5.基金项目
河北省医学科学研究课题计划(No.20241320) （No.20241320）
