中国医院用药评价与分析2025，Vol.25Issue(4)：469-473,478,6.DOI:10.14009/j.issn.1672-2124.2025.04.019
抗肿瘤药物相关毛细血管渗漏综合征发生率的Meta分析
Meta-Analysis on the Incidence of Capillary Leakage Syndrome Induced by Anti-Tumor Drugs
摘要
Abstract
OBJECTIVE:To perform Meta-analysis on the incidence of adverse drug reactions associated with capillary leakage syndrome(CLS)during the treatment of anti-tumor drugs,and provide reference for safe medication in the clinic.METHODS:Embase,the Cochrane library,PubMed,and CNKI were retrieved to collect randomized controlled trials(RCT)of CLS during the treatment of anti-tumor drugs up to Apr.1st,2024.Literature that met the criteria was included and evaluated for quality,and RevMan 5.4 software was used for Meta-analysis.RESULTS:A total of 70 articles were enrolled,including 3 002 patients.Meta-analysis showed that interleukin-2 alone or in combination with other drugs had the highest incidence of CLS(29%),followed by interleukin-1,interleukin-3 and interleukin-4(23%).The incidence of CLS induced by anti-CD monoclonal antibody drugs,granulocyte-macrophage colony-stimulating factor and gemcitabine was 21%,10%and 3%,respectively.CONCLUSIONS:Interleukin drugs are most likely to cause CLS,and it is important to monitor adverse drug reactions to improve medication safety.关键词
毛细血管渗漏综合征/抗肿瘤药物/免疫调节剂/不良反应/Meta分析Key words
Capillary leakage syndrome/Anti-tumor drug/Immunomodulator/Adverse reaction/Meta-analysis分类
医药卫生引用本文复制引用
康烨,刘家荟,孙雪,刘鑫..抗肿瘤药物相关毛细血管渗漏综合征发生率的Meta分析[J].中国医院用药评价与分析,2025,25(4):469-473,478,6.基金项目
辽宁省科技计划联合计划应用基础研究项目(No.2023JH2/101700113) （No.2023JH2/101700113）
