中国中医药信息杂志2025，Vol.32Issue(5)：55-61,7.DOI:10.19879/j.cnki.1005-5304.202410495
基于超网络的西南地区治疗闭经用药规律研究
Study on the Medication Law of Amenorrhea in Southwest China Based on Hypergraph
摘要
Abstract
Objective To explore the compatibility law of amenorrhea and commonly used local herbs in southwest China using hypergraph;To provide drug choice for the clinical treatment of modern TCM amenorrhea and promote the development and utilization of local Chinese materia medica resources.Methods In this study,the data of prescriptions for the treatment of amenorrhea in Southwest China were used as the data source.By constructing formulas related to amenorrhea-hypergraph(AFR-HG),the topological structure of AFR-HG was analyzed,and the core subnet was extracted according to the node weighted hypercentrality.Based on the sub-network AFR-HG-p1 extracted from the top 20 kinds of Chinese materia medica in AFR-HG,the Kumar algorithm was used to divide the efficacy community network.Results A total of 123 amenorrhea prescriptions were included in this study.Angelicae Sinensis Radix,Carthami Flos,Cyperi Rhizoma,Chuanxiong Rhizoma and other drugs with the efficacy of promoting blood circulation and removing blood stasis,soothing liver and regulating qi,and warming and tonifying were the main drugs with high frequency.Three layers of core subnets were extracted layer by layer through weighted hyper-centrality sorting.The first layer contained Angelicae Sinensis Radix,Chuanxiong Rhizoma,Hyperici Sampsonii Herba,etc.;the second layer of drugs were mainly Lycopi Herba,Rubiae Radix et Rhizoma,Bombycis Feculae,etc.;the third layer of drugs were mainly Ginseng Radix et Rhizoma Rubra,Moutan Cortex,Sargentodoxae Caulis and other drugs;based on the top 20 node overdose drugs,community drugs were obtained through community detection:the first community subnet was Armeniacae Semen Amarum,Draconis Sanguis,Corydalis Rhizoma,etc.,the second community subnet was Rubiae Radix et Rhizoma,Rosae Chinensis Flos,Hyperici Sampsonii Herba,etc.,and the third community subnet was Akebiae Caulis,Homalomenae Rhizoma,Bombycis Feculae,etc.Conclusion In prescriptions of amenorrhea in Southwest China,the treatment principles are basically consistent with modern clinical practice.In addition to commonly used drugs,local herbal medicines and similar medicines are also common.It is of great value to explore the rules of prescriptions for the development and utilization of Chinese materia medica resources.关键词
超网络/闭经/数据挖掘/用药规律Key words
hypergraph/amenorrhoea/data mining/medication law分类
中医学引用本文复制引用
田思玮,张卫,李兵,李玮婕,王晶爱,王嘉伦,张华敏,曾子玲..基于超网络的西南地区治疗闭经用药规律研究[J].中国中医药信息杂志,2025,32(5):55-61,7.基金项目
中国中医科学院科技创新工程(CI2021A03711、CI2023E002) （CI2021A03711、CI2023E002）
国家重点研发计划(2023YFC3502900) （2023YFC3502900）
中央级公益性科研院所基本科研业务费专项资金(ZZ16-XRZ-073、ZZ17-YQ-056) （ZZ16-XRZ-073、ZZ17-YQ-056）
