中国中医药图书情报杂志2025，Vol.49Issue(3)：26-32,7.DOI:10.3969/j.issn.2095-5707.202405013
基于网络药理学和分子对接技术探讨黄芪消渴方治疗2型糖尿病作用机制
Exploration on the Mechanism of Huangqi Xiaoke Decoction in the Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking
摘要
Abstract
Objective To explore the mechanism of Huangqi Xiaoke Decoction in the treatment for type 2 diabetes mellitus(T2DM)by using network pharmacology and molecular docking.Methods TCMSP and SymMap databases were retrieved to obtain the active components of Huangqi Xiaoke Decoction and potential targets were predicted.GeneCards and DisGeNET databases were used to obtain the related targets of T2DM.A Venn diagram was drawn to identify common targets between the active components and the disease.The Cytoscape 3.7.2 software was used to construct the active component-target network,PPI network and core target network.GO and KEGG pathway enrichment analysis were performed using Metascape.Finally,AutoDockTools and PyMOL software were used for molecular docking verification.Results Totally 142 active components and 2 458 disease targets of Huangqi Xiaoke Decoction were included,with 437 potential targets for treating T2DM,including AKT1,GAPDH,IL6,etc.;a total of 3 802 GO functional terms and 248 KEGG pathways were enriched.Molecular docking results indicated that the components binds stably to the core target proteins.Conclusion Huangqi Xiaoke Decoction may exert its therapeutic effects on T2DM through targets such as AKT1,GAPDH and IL6,as well as signaling pathways including cancer pathways,insulin resistance and calcium signaling pathways.关键词
黄芪消渴方/2型糖尿病/网络药理学/分子对接/作用机制Key words
Huangqi Xiaoke Decoction/type 2diabetes mellitus/network pharmacology/molecular docking/mechanism分类
医药卫生引用本文复制引用
曾丽微,龚丽,柳治宇,黄凤怡,曾纪斌..基于网络药理学和分子对接技术探讨黄芪消渴方治疗2型糖尿病作用机制[J].中国中医药图书情报杂志,2025,49(3):26-32,7.基金项目
河源市社会发展科技计划项目(2023年) （2023年）
