中成药2025，Vol.47Issue(4)：1097-1104,8.DOI:10.3969/j.issn.1001-1528.2025.04.005
人参皂苷缓释微球制备
Preparation of sustained-release microspheres of ginsenosides
摘要
Abstract
AIM To prepare the sustained-release microspheres of ginsenosides.METHODS The sustained-release microspheres were prepared by SPG membrane emulsification technology with poly(lactic-co-glycolic acid)(PLGA)as a shell carrier.With PLGA concentration,feed rate and Span 60 concentration as influencing factors,comprehensive score for appearance,drug loading and encapsulation efficiency as an evaluation indice,the preparation process was optimized by response surface method.The morphology of sustained-release microspheres was observed,after which the particle size,drug loading and encapsulation efficiency were determined,and the in vitro drug release was investigated.RESULTS The optimal conditons were determined to be 45 s for agitation time of primary emulsion,74.68 mg/mL for PLGA concentration,11％for feed rate,and 4.18 mg/mL for Span 60 concentration,the comprehensive score was 74.98.The round sustained-release microspheres demonstrated the average particle size of 4.33 μm,drug loading of(8.24±0.13)％,and encapsulation efficiency of(74.94±1.17)％,respectively.At 336 h,ginsenosides Rg1,Rb1,Rb2 displayed the accumulative release rates of 84.12％,78.04％,65.88％,respectively.CONCLUSION This reasonable and feasible method can be used for the preparation of sustained-release microspheres of ginsenosides with good appearance and high drug loading,which can provide references for the preparation of other water-soluble drug microspheres and solution of microsphere collapse problem.关键词
人参皂苷/缓释微球/制备工艺/聚乳酸-羟基乙酸共聚物(PLGA)/SPG膜乳化技术Key words
ginsenosides/sustained-release microspheres/preparation process/poly(lactic-co-glycolic acid)(PLGA)/emulsification technology分类
医药卫生引用本文复制引用
刘相莹,何汝楠,邱高,林宗浩,郭玉海,余楚钦..人参皂苷缓释微球制备[J].中成药,2025,47(4):1097-1104,8.基金项目
国家自然科学基金(82174405) （82174405）
广东省药品监督管理局科技创新项目(2021TDB40) （2021TDB40）
林芝市科技计划项目(2023-YZ-01) （2023-YZ-01）
