中成药2025，Vol.47Issue(4)：1104-1111,8.DOI:10.3969/j.issn.1001-1528.2025.04.006
紫菀中5种有效成分在大鼠体内药动学研究
In vivo pharmacokinetics of five effective constituents in Asteris Radix et Rhizoma in rats
摘要
Abstract
AIM To investigate the in vivo pharmacokinetics of chlorogenic acid,isoquercetin,ferulic acid,isorhamnetin and shionone in Asteris Radix et Rhizoma in rats.METHODS Twelve rats were randomly assigned into 2 groups and given intragastric administration of conventional dose(0.63 g/kg)and large dose(3.3 g/kg)of Asteris Radix et Rhizoma extracts,respectively,after which blood collection was made at 0.083,0.167,0.33,0.5,0.75,1,1.5,2,4,6,8,12,24 h,UPLC-MS/MS was adopted in the plasma concentration determination of various effective constituents,and main pharmacokinetic parameters were calculated.RESULTS Various effective constituents in the large dose group demonstrated prolonged t1/2,MRT0-∞ as compared with those in the conventional dose group(P＜0.05).After dose correction,Cmax of chlorogenic acid,isoquercetin,shionone in the large dose group displayed no obvious changes(P＞0.05),while Cmax of ferulic acid,isorhamnetin,and AUC0-t,AUC0-∞ of various effective constituents were higher than those in the conventional dose group(P＜0.05).CONCLUSION Various effective constituents in the high dose of Asteris Radix et Rhizoma can maintain high-concentration and long-time effects on rat bladder tissue.关键词
紫菀/有效成分/体内药动学/UPLC-MS/MSKey words
Asteris Radix et Rhizoma/effective constituents/in vivo pharmacokinetics/UPLC-MS/MS分类
医药卫生引用本文复制引用
范玲,汪明志,吴燕,顾佳美,赵雅杰,王鑫..紫菀中5种有效成分在大鼠体内药动学研究[J].中成药,2025,47(4):1104-1111,8.基金项目
苏州市科技发展计划(SKYXD2022012) （SKYXD2022012）
