摘要
Abstract
Objective To systematically evaluate the efficacy and safety of intravenous ginkgo biloba leaf preparation in the treatment of acute ischemic stroke(AIS).Methods Randomized controlled trials of intravenous ginkgo biloba leaf preparation in the treatment of AIS in English databases such as PubMed,Embase,and Cochrane Library,as well as in Chinese databases like Wanfang,CNKI,and VIP were searched by computer.The search period was from the establishment of these databases to July 30,2024.The quality of the included literature was evaluated using the Cochrane RevMan bias risk assessment table.Using RevMan 5.3 software,a meta-analysis was performed on prognosis,early neurological improvement,neurological deficits,total effective rate,adverse reactions,and other indicators of ginkgo biloba leaf preparation in the treatment of AIS.Results A total of 9 articles were included in this study,including 3 in English and 6 in Chinese,which involved 6111 patients,comprising 3103 in the control group and 3008 in the experimental group.The meta-analysis results showed that intravenous ginkgo biloba leaf preparation could improve the rate of good prognosis(mRS score≤2 points)of AIS patients(OR1.95,95%CI1.72-2.22,P＜0.001),reduce the mRS score[standardized mean difference(SMD)-0.67,95%CI-0.76--0.58,P＜0.001],enhance the rate of early neurological improvement of patients(OR1.23,95%CI1.07-1.41,P=0.003),and decrease the NIHSS score of patients(SMD-1.36,95%CI-1.54--1.17,P＜0.001).Ginkgo biloba leaf preparation could improve the total effective rate of AIS treatment(OR3.68,95%CI1.81-7.49,P＜0.001),without increasing the incidence of adverse reactions(OR1.01,95%CI0.85-1.20,P=0.870).Conclusions Intravenous ginkgo biloba leaf preparation has a brain cytoprotection effect on AIS and can improve the prognosis of patients without increasing adverse reactions.关键词
急性缺血性卒中/银杏叶提取物/神经功能/预后/不良反应Key words
Acute ischemic stroke/Ginkgo biloba leaf preparation/Neurological function/Prognosis/Adverse reaction分类
临床医学
