转化医学杂志2025，Vol.14Issue(3)：5-10,6.DOI:10.3639/j.issn.2095-3097.2025.03.002
血清GM-CSF、sCD163水平与难治性肺炎支原体肺炎患儿病情及预后的关系
Relationship between Serum GM-CSF and sCD163 Levels and the Condition and Prognosis of Children with Refractory Mycoplasma Pneumoniae Pneumonia
摘要
Abstract
Objective To investigate the relationship between the levels of serum granulocyte-macrophage colo-ny-stimulating factor(GM-CSF)and soluble cluster of differentiation 163(sCD163)and the disease severity and prognosis in children with refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods A total of 152 children with RMPP(RMPP group),60 children with general Mycoplasma pneumoniae pneumonia(GMPP group),and 60 healthy children who under-went physical examination during the same period(control group)were enrolled from January 2021 to April 2024 at The First People's Hospital of Mengcheng County.The RMPP patients were further classified into severe RMPP group(n=81)and mild RMPP group(n=71)based on disease severity,and into poor prognosis group(n=55)and good prognosis group(n=97)based on 28-day prognosis.Enzyme-linked immunosorbent assay was used to measure the serum levels of GM-CSF and sCD163.The prognosis of RMPP children was taken as the dependent variable,and multivariate unconditional Logistic regression anal-ysis was conducted to determine its influencing factors.Receiver operating characteristic(ROC)curves were plotted to ana-lyze the predictive efficacy of serum GM-CSF and sCD163 levels.Results The serum levels of GM-CSF and sCD163 in the RMPP group[(12.96±4.17)ng/mL,(188.88±28.23)pg/mL]were significantly higher than those in the GMPP group[(9.40±2.29)ng/mL,(148.49±24.00)pg/mL]and the control group[(4.58±1.17)ng/mL,(99.18±20.30)pg/mL](both P<0.01).The serum levels of GM-CSF and sCD163 in the severe RMPP group[(11.37±3.97)ng/mL,(178.19±25.88)pg/mL)]were signifi-cantly below those in the mild RMPP group[(14.77±3.64)ng/mL,(201.07±25.91)pg/mL](both P<0.01).The serum levels of GM-CSF and sCD163 in the poor prognosis group[(15.55±3.61)ng/mL,(207.13±23.66)pg/mL]were significantly higher than those in the good prognosis group[(11.49±3.74)ng/mL,(178.53±25.29)pg/mL](both P<0.01).Independent risk factors for poor prognosis in RMPP children included prolonged fever(OR=1.515,95%CI:1.120-2.049),severe RMPP(OR=5.615,95%CI:1.992-15.829),high GM-CSF(OR=1.284,95%CI:1.114-1.480),and high sCD163(OR=1.046,95%CI:1.023-1.069)(all P<0.05).The area under the ROC curve(AUC)for the combined prediction of poor prognosis using serum GM-CSF and sCD163 levels was 0.861(95%CI:0.796-0.912),which was higher than the AUC for GM-CSF alone(0.784,95%CI:0.710-0.846)and sCD163 alone(0.785,95%CI:0.711-0.847)(both P<0.05).Conclusion Elevated serum levels of GM-CSF and sCD163 in children with RMPP are associated with increased disease severity and poor prognosis.The combined measurement of serum GM-CSF and sCD163 levels exhibits high predictive efficacy for poor prognosis in RMPP patients.关键词
儿童/难治性肺炎支原体肺炎/粒细胞-巨噬细胞集落刺激因子/可溶性分化簇163/病情/预后Key words
Children/Refractory mycoplasma pneumoniae pneumonia/Granulocyte-macrophage colony-stimulating factor/Soluble cluster of differentiation 163/Disease severity/Prognosis分类
基础医学引用本文复制引用
陈雷,龚倩,程海燕,沈怀云..血清GM-CSF、sCD163水平与难治性肺炎支原体肺炎患儿病情及预后的关系[J].转化医学杂志,2025,14(3):5-10,6.基金项目
安徽省临床医学研究转化专项项目(202304295107020050) （202304295107020050）
