转化医学杂志2025，Vol.14Issue(3)：22-27,6.DOI:10.3639/j.issn.2095-3097.2025.03.005
妊娠期合并甲状腺功能减退发生相关因素分析及干预对策实施:一项关于Logistic的研究
Analysis of Factors Associated with the Occurrence of Combined Hypothyroidism in Pregnancy and Implementation of Intervention Measures:A Logistic Study
摘要
Abstract
Objective To study the factors associated with the occurrence of combined hypothyroidism in pregnancy,and to develop targeted intervention measures.Methods 312 cases of pregnant women in pregnancy were retrospectively se-lected from June 2021 to August 2023,among which 25 cases were dropped,the reasons for which were loss of visits and incom-plete case data,and 287 cases were finally obtained for complete follow-up,which were grouped according to whether they were combined with hypothyroidism or not,and the pregnant women with hypothyroidism were included in the combined group,and those who did not were included in the normal group.Clinical data of the two groups were compared,and the influencing factors with statistically significant differences in the univariate analysis were included in the logistic regression for analysis to obtain the factors associated with combined hypothyroidism in pregnancy.Results A total of 287 pregnant women during pregnancy were included,of which 46 cases of combined hypothyroidism,with an incidence of 16.03%.The differences in pre-pregnancy body mass index(BMI),number of deliveries,thyroid peroxidase antibody(TPOAb),smoking/passive smoking,iodine intake during pregnancy,gestational diabetes mellitus,and family history of thyroid disorders in the combined group compared to the normal group was significant(P<0.05).After the diagnosis of covariance,the VIF values of smoking/passive smoking and family history of thyroid disease were 8.690 and 38.618,respectively,with a tolerance of 0.115 and 0.026,which indicated that the item had a problem of covariance(VIF value>5),and it could be considered to be moved out of the model and then analysed again.Finally,the results were calculated by logistic regression analysis,which showed that pre-pregnancy BMI,number of deliveries,TPOAb,iodine intake during pregnancy,and gestational diabetes mellitus were all influential factors for combined hypothyroidism during pregnancy.Based on the results of the logistic regression analysis,a column chart model was constructed to predict the risk of combined hypothyroidism in pregnancy,and a calibration curve was plotted,which was found to be close to the ideal curve for predicting the occurrence of combined hypothyroidism in pregnancy.Conclusion The risk of combined hypothyroidism in preg-nancy is high,which may be influenced by pre-pregnancy BMI,number of deliveries,TPOAb,iodine intake during pregnancy,gestational diabetes mellitus,etc.Clinical attention should be paid to the development of early interventions in order to reduce or prevent the occurrence of hypothyroidism.关键词
甲状腺功能减退/妊娠期/初产妇/妊娠糖尿病Key words
Hypothyroidism/Pregnancy/Primigravida/Gestational diabetes mellitus分类
医药卫生引用本文复制引用
王欣怡,刘艳秋,朱骏,徐玲..妊娠期合并甲状腺功能减退发生相关因素分析及干预对策实施:一项关于Logistic的研究[J].转化医学杂志,2025,14(3):22-27,6.基金项目
江苏省妇幼健康科研项目(F202101) （F202101）
