中成药2025，Vol.47Issue(4)：1181-1188,8.DOI:10.3969/j.issn.1001-1528.2025.04.018
罗汉果根化学成分及其α-葡萄糖苷酶抑制活性研究
Chemical constituents from the roots of Siraitia grosvenorii and their α-glucosidase inhibitory activities
摘要
Abstract
AIM To study the chemical constituents from the roots of Siraitia grosvenorii(Swingle)C.Jeffrey and their α-glucosidase inhibitory activities.METHODS The 95％ethanol extract was isolated and purified by silica gel,MCI,ODS and HSCCC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The α-glucosidase inhibitory activities were evaluated by PNPG method,after which molecular docking was performed.RESULTS Twenty-one compounds were isolated and identified as vanillin(1),siraitic acid B(2),cucurbitacin B(3),salicylic acid(4),ferulic acid(5),p-hydroxybenzaldehyde(6),(+)-lariciresinol(7),(+)-isolariciresinol(8),liballinol(9),3-(hydroxyacetyl)indole(10),2E-4-hydroxy-nonenoic acid(11),vomifolilol(12),vanillic acid(13),indole-3-carboxylic acid(14),ω-hydroxypropioguaiacone(15),p-hydroxybenzoic acid(16),p-coumaric acid(17),dehydrodipinocarpine(18),secoisolariciresinol(19),sesquimarocanol A(20),threo-guaiacylglycerol-β-O-4-lariciresinol ether(21).IC50 values of compounds 4,10,18 and 21 were(0.42±0.060)-(0.89±0.037)mg/mL.CONCLUSION Compounds 4,10-12,15,16,18,and 21 are isolated from the roots of this plant for the first time.Compounds 4,10,18,21 have α-glucosidase inhibitory activities,and 18 has the strongest activity.关键词
罗汉果/根/化学成分/分离鉴定/α-葡萄糖苷酶/分子对接Key words
Siraitia grosvenorii(Swingle)C.Jeffrey/roots/chemical constituents/isolation and identification/α-glucosidase/molecular docking分类
医药卫生引用本文复制引用
韦思宇,韦玉璐,卢凤来,隆文龙,蒋小华..罗汉果根化学成分及其α-葡萄糖苷酶抑制活性研究[J].中成药,2025,47(4):1181-1188,8.基金项目
广西科技重大专项(桂科AA22096020,桂科AA23023035) （桂科AA22096020,桂科AA23023035）
广西科技基地和人才专项(桂科AA21196009) （桂科AA21196009）
桂林市创新平台和人才计划(20210102-3,20220120-3) （20210102-3,20220120-3）
