转化医学杂志2025，Vol.14Issue(3)：45-49,5.DOI:10.3639/j.issn.2095-3097.2025.03.010
血清LRP6、PTRF水平对胫骨骨折患者术后骨折愈合情况的预测价值
Prognostic Value of Serum LRP6,PTRF on Fracture Healing in Cases with Tibial Fracture after Operation
摘要
Abstract
Objective To investigate the predictive value of serum levels of low density lipoprotein receptor-associated protein 6(LRP6),polymerase 1 and transcription release factor(PTRF)on fracture healing in patients with tibial fracture(TF)after surgery.Methods 117 cases with TF from March 2021 to February 2024 were selected.The patients were followed up for 4 months and divided into the normal healing group(n=96)and the delayed healing group(n=21).Serum LRP6 and PTRF levels were compared between the two groups.The predictive value of serum LRP6 and PTRF for fracture healing in patients with TF was evaluated by ROC.The influencing factors of postoperative fracture healing in TF patients were explored using multivariate Logistic regression.Results The serum levels of LRP6 and PTRF in the delayed healing group were lower than those in the normal healing group(P<0.05).The area under the curve(AUC)(95%CI)of serum LRP6,PTRF and their combination in pre-dicting postoperative fracture healing in TF patients was 0.872(0.802-0.924),0.745(0.693-0.797)and 0.903(0.851-0.955),respectively.The delayed healing group had higher proportions of age,diabetes history,open fracture,complete weight-bearing time≥3 months,postoperative local infection and postoperative osteofascial compartment syndrome compared to the normal healing group(P<0.05).Multivariate analysis showed that.diabetes history(OR=2.115,95%CI:1.437-3.112),postoperative lo-cal infection(OR=2.380,95%CI:1.568-3.613),postoperative osteofascial compartment syndrome(OR=2.529,95%CI:1.669-3.833),LRP6<17.26 ng/mL(OR=0.300,95%CI:0.189-0.476),and PTRF<35.52 ng/L(OR=0.406,95%CI:0.270-0.610)were independent risk factors for delayed fracture healing(P<0.05).Conclusion Serum LRP6 and PTRF have predictive value for postoperative fracture healing in TF patients,with higher predictive power when combined.关键词
胫骨骨折/骨折愈合/低密度脂蛋白受体相关蛋白6/聚合酶1和转录释放因子Key words
Tibial fracture/Fracture healing/Low density lipoprotein receptor-associated protein 6/Polymerase 1 and transcription release factor分类
临床医学引用本文复制引用
王臣,田彪,徐贺轩,赵亚菲,赵吉堂..血清LRP6、PTRF水平对胫骨骨折患者术后骨折愈合情况的预测价值[J].转化医学杂志,2025,14(3):45-49,5.基金项目
河北省2024年度医学科学研究课题计划(20241451) （20241451）
