转化医学杂志2025，Vol.14Issue(3)：56-60,5.DOI:10.3639/j.issn.2095-3097.2025.03.012
胸腹水LMR、EOS、LDH联合检测对良恶性胸腹腔积液的鉴别诊断价值
The Value of Lmr,Eos and Ldh Combined Detection in Differential Diagnosis of Benign and Malignant Pleuroperitoneal Effusion
摘要
Abstract
Objective To investigate the value of combined determination of lymphocyte-to-monocyte ratio(LMR),eosinophilic granulocyte(EOS)and lactate dehydrogenase(LDH)in the differential diagnosis of benign and malignant pleuro-peritoneal effusions.Methods A total of 252 patients with pleuroperitoneal effusions admitted to our hospital from October 2021 to September 2023 were selected as the subjects,123 patients with benign lesions confirmed by surgical pathology were selected as the benign group,and 129 patients with cancer were selected as the malignant group by case-control study.A fully automated blood cell analyzer was used to detect lymphocytes,monocytes,and EOS in pleural or peritoneal fluid,with LMR calculated.A biochemical analyzer to detect LDH was used in pleural and peritoneal fluid.The diagnostic value of LMR,EOS and LDH in benign and malignant pleuroperitoneal effusion were evaluated by receiver operating characteristic(ROC)curves.Results The LMR,EOS and LDH levels in the benign group were lower than those in the malignant group(P<0.05).The AUCs of LMR,EOS and LDH in the diagnosis of benign and malignant pleuroperitoneal effusions were 0.814,0.753 and 0.619,re-spectively,and the AUC of the combined diagnosis was 0.938.The specificity of pleural fluid LMR in the diagnosis of malignant pleural fluid was the highest(0.659),followed by EOS and LDH(0.618 and 0.577,respectively).LDH had the highest sensitivity in the diagnosis of malignant pleuroperitoneal effusion(0.860),followed by EOS and LMR(0.760 and 0.744,respectively).The diagnostic specificity and sensitivity of the three indexes combined can reach 0.886 and 0.915.Conclusion The combined detection of LMR,EOS and LDH in pleural and abdominal fluid has high clinical value for differential diagnosis of benign and malignant pleural and abdominal effusions.关键词
淋巴细胞-单核细胞比值/嗜酸性粒细胞/乳酸脱氢酶/恶性胸腹腔积液Key words
lymphocyte-monocyte ratio/Eosinophils/Lactate dehydrogenase/Malignant pleuroceliac effusion分类
医药卫生引用本文复制引用
文柯,王琼,靳德甫,李畅,嵇金陵..胸腹水LMR、EOS、LDH联合检测对良恶性胸腹腔积液的鉴别诊断价值[J].转化医学杂志,2025,14(3):56-60,5.基金项目
南京医科大学科技发展基金(NMUB2019357) （NMUB2019357）
