转化医学杂志2025，Vol.14Issue(3)：61-65,5.DOI:10.3639/j.issn.2095-3097.2025.03.013
颈动脉内膜剥脱术治疗颈动脉狭窄的疗效及预后危险因素分析
Analysis of the Curative Effect and Prognostic Risk Factors of Carotid Artery Stenosis Treated by Carotid Endarterectomy
摘要
Abstract
Objective To explore the efficacy and risk factors ofcarotid endarterectomy(CEA)in the treatment of ca-rotid artery stenosis.Methods A retrospective study was conducted on 126 patients with CEA admitted to the Department of Neurology in Jiayuguan First People's Hospital from February 2018 to July 2022.The mean flow velocity of the middle cerebral artery(MVmcA),pulsatile index(PI),and incidence of poor prognosis were evaluated.Logistic regression model was used to analyze the risk factors for poor prognosis.Results At 5 days and 12 months after surgery,MVmcA and PI levels were signifi-cantly higher in all subjects than before surgery,and the difference was statistically significant(P<0.05);there was no statisti-cally significant difference in MVmcA and PI levels between 12 months after surgery and 5 days after surgery(P>0.05).Among the 126 patients who underwent CEA surgery,24(19.05%)had poor prognosis,including 4(16.67%)with stroke,5(20.83%)with cardiovascular adverse events,3(12.50%)with cranial nerve injury,7(29.17%)with local hematoma,and 5(20.83%)with restenosis after CEA.The univariate results showed that the presence of hyperlipidemia,use of a bypass catheter,history of smoking,degree of carotid artery stenosis,and duration of carotid artery occlusion were associated with poor prognosis in pa-tients after CEA surgery,and the differences were statistically significant(P<0.05).The results of multivariate logistic regression showed that the presence of hyperlipidemia,smoking history,and non-use of diversion catheter were risk factors for poor prog-nosis in patients after CEA surgery(P<0.05).Conclusion CEA treatment can effectively improve cerebral blood flow perfusion in patients with carotid artery stenosis,with good therapeutic effects;patients who have high blood lipids,a history of smoking,and have not used a catheter after CEA surgery are more likely to have poor prognosis.Clinically,the incidence of poor progno-sis in CEA patients can be reduced based on their risk factors.关键词
颈动脉内膜切除/颈动脉狭窄/预后不良Key words
Carotid endarterectomy/Carotid artery stenosis/Poor prognosis分类
医药卫生引用本文复制引用
万兴忠,唐博,张勇,贾文杰,姚启龙..颈动脉内膜剥脱术治疗颈动脉狭窄的疗效及预后危险因素分析[J].转化医学杂志,2025,14(3):61-65,5.基金项目
嘉峪关市科技计划项目(21-29) （21-29）
