转化医学杂志2025，Vol.14Issue(3)：71-76,6.DOI:10.3639/j.issn.2095-3097.2025.03.015
C反应蛋白/白蛋白比值与老年脑梗死合并肺部感染的关系及对患者预后的预测价值
The Relationship between C-reactive Protein/Albumin Ratio and Cerebral Infarction Complicated with Pulmonary Infection in Elderly Patients and Its Prognostic Value
摘要
Abstract
Objective To analyze the relationship between C-reactive protein/albumin ratio(CRP/ALB)and pulmonary infection in elderly patients with cerebral infarction and its prognostic value.Methods A retrospective analysis was conducted on 380 elderly patients with cerebral infarction admitted to our hospital from January 2021 to December 2023,and the patients were divided into lung infection group(n=122)and non-infection group(n=258)based on hospital-acquired infection status.The patients with cerebral infarction combined with pulmonary infection were divided into poor prognosis group(n=30)and good prognosis group(n=92)according to the prognosis at 6 months after treatment.Serum C-reactive protein(CRP)and albumin(ALB)levels were detected in all subjects after admission,and CRP/ALB ratio was calculated.The value of CRP/ALB ratio in the prognosis of elderly patients with cerebral infarction combined with pulmonary infection was analyzed by receiver operating characteristic(ROC)curve.Meanwhile,the risk factors of prognosis in elderly patients were explored by multi-factor logistics regression analysis.Results The National Institutes of Health Stroke Scale(NIHSS)score,serum CRP and CRP/ALB ratio in pulmonary infection group were higher than those in non-infection group,and the ALB level was lower than that in non-infection group(P<0.05).The NIHSS score,serum CRP and CRP/ALB ratio in the poor prognosis group were higher than those in the good prognosis group,and the ALB level was lower than that in the good prognosis group(P<0.05).ROC curve results showed that the AUC of serum CRP and ALB in predicting the prognosis of elderly patients with cerebral infarction combined with pulmonary in-fection were 0.804(95%CI:0.754-0.854)and 0.851(95%CI:0.801-0.901),respectively.CRP/ALB ratio predicted the prognosis of elderly patients with cerebral infarction combined with pulmonary infection,and the AUC was 0.905(95%CI:0.855-0.955).Multivariate regression analysis showed that CRP>30.33 mg/L(OR=3.047,95%CI:1.732-5.357),ALB≤28.96 g/L(OR=2.776,95%CI:1.687-4.567),CRP/ALB ratio>1.28(OR=4.225,95%CI:2.078-8.589)were risk factors for prognosis in elderly patients with cerebral infarction combined with pulmonary infection(P<0.05).Conclusion CRP/ALB is abnormally elevated in elderly patients with cerebral infarction complicated with pulmonary infection,and is closely related to prognosis,which is expected to be an effective biological indicator to evaluate the prognosis of patients.关键词
脑梗死/肺部感染/老年人/C反应蛋白/白蛋白比值/预后Key words
Cerebral infarction/Lung infection/The elderly/C-reactive protein/albumin ratio/Prognosis分类
医药卫生引用本文复制引用
杨小钧,陈硕,徐旭慧,周庆坤,韩莉,王加林,刘艳..C反应蛋白/白蛋白比值与老年脑梗死合并肺部感染的关系及对患者预后的预测价值[J].转化医学杂志,2025,14(3):71-76,6.基金项目
江苏省自然科学基金(BK20220236) （BK20220236）
