转化医学杂志2025，Vol.14Issue(1)：47-51,5.DOI:10.3639/i.issn.2095-3097.2025.01.010
DFR对急性脑梗死患者机械取栓后出血性转化的评估价值
DFR in Evaluating Hemorrhagic Transformation After Mechanical Thrombectomy in Patients with Acute Cerebral Infarction
摘要
Abstract
Objective To investigate the value of D-dimer(D-D)/fibrinogen(FIB)ratio(DFR)in evaluating hemorrhagic transformation(HT)after mechanical thrombectomy in patients with acute cerebral infarction(ACI).Methods A total of 120 patients with acute cerebral infarction who underwent mechanical thrombectomy at our hospital from January 2021 to December 2023 were included.They were divided into an HT group(n=46)and a non-HT group(n=74)based on whether HT occurred within 3 days post-thrombectomy.D-D and FIB levels were measured using immunoturbidimetry,and DFR was calculated.The value of D-D,FIB,and DFR for predicting HT after thrombectomy was analyzed using ROC curves.Risk factors for HT were evaluated via multivariate Logistic regression.Results The HT group showed significantly higher D-D and DFR and lower FIB levels than the non-HT group(P<0.05).The AUC for predicting HT was 0.724(95%CI:0.679-0.774)for D-D,0.876(95%CI:0.826-0.921)for FIB,and 0.942(95%CI:0.892-0.987)for DFR.The HT group also had higher rates of smoking history,diabetes,elevated preoperative NIHSS scores,and postoperative systolic blood pressure compared to the non-HT group(P<0.05).Preoperative NIHSS score≥14 points(OR=2.524,95%CI:1.383-4.608),postoperative systolic blood pressure≥137 mmHg(OR=2.119,95%CI:1.236-3.633),D-D≥1.68 mg/L(OR=2.971,95%CI:1.637-5.392),FIB≤2.87 g/L(OR=3.238,95%CI:1.813-5.392),and DFR≥0.61(OR=4.023,95%CI:2.292-7.061)were identified as independent risk factors for HT.Conclusion High DFR is a significant risk factor for HT in ACI patients post-mechanical thrombectomy and can serve as a clinical marker for evaluation.关键词
D-二聚体/纤维蛋白原比值/急性脑梗死/机械取栓/出血性转化Key words
D-dimer/fibrinogen ratio/Acute cerebral infarction/Mechanical thrombectomy/Hemorrhagic transformation分类
医药卫生引用本文复制引用
魏统国,陈丹霞,钟裕,朱钦辉,徐昆明..DFR对急性脑梗死患者机械取栓后出血性转化的评估价值[J].转化医学杂志,2025,14(1):47-51,5.基金项目
广东省卫生健康委员会科研项目(20221216) （20221216）
2023年度梅州市社会发展科技计划项目(2023B28) （2023B28）
