转化医学杂志2025，Vol.14Issue(1)：105-111,7.DOI:10.3639/i.issn.2095-3097.2025.01.022
支气管动脉灌注化疗联合信迪利单抗序贯根治性放疗治疗大肿块Ⅲ期鳞状非小细胞肺癌:一项单中心、单臂研究
Bronchial Arterial Infusion Chemotherapy Combined with Sintilimab Followed by Radical Radiotherapy in the Treatment of Large Stage Ⅲ Squamous Non-small Cell Lung Cancer:a Single-center,Single-arm Study
摘要
Abstract
Objective To explore the efficacy and safety of bronchial arterial infusion(BAI)chemotherapy combined with immune checkpoint inhibitors followed by radical radiotherapy in the treatment of large mass stage Ⅲ squamous non-small cell lung cancer.Methods Sixteen patients with inoperable stage Ⅲ squamous non-small cell lung cancer who were treated in the First People's Hospital of Yibin from August 2021 to December 2023 were included and underwent BAI combined with immunotherapy,followed by radical radiotherapy.Results Among the 16 patients,the 1-year and 2-year progression-free survival(PFS)rates were 87.5%(14 case)and 46.41%(8 case),respectively,and the median progression-free survival(mPFS)was 24.03 months.The 1-year and 2-year overall survival(OS)rates were 93.75%(15 case)and 66.20%(11 case)respectively,and the median overall survival(mOS)was not reached.The objective response rate(ORR)after BAI chemotherapy combined with immunotherapy was 56.25%(9/16),and after radical radiotherapy it was 75.00%(12/16).In terms of safety,the total incidence rate of adverse events was 93.75%,including 43.75%(7/16)pneumonia,1 case(6.25%)in grade 3(G3),and 1 case(6.25%)in G5.Conclusion BAI combined with immunotherapy and sequential radical radiotherapy have certain safety and efficacy in patients with stage Ⅲ lung squamous cell carcinoma with large tumor masses.However,given the limited sample size of the included studies and the heterogeneity of the treatments used,the findings need further validation in larger clinical trials.关键词
癌,非小细胞肺/肿瘤,鳞状细胞/化学疗法,肿瘤,局部灌注/免疫检查点抑制剂/放射疗法/疗效比较研究Key words
Cancer,non-small cell lung/Tumor,squamous cells/Chemotherapy/Tumor/Local perfusion/Immune checkpoint inhibitors/Radiation therapy/Comparative study of curative effect分类
医药卫生引用本文复制引用
陈小春,袁志平,林川,毕红亲,王昌平,李倩,邓万兵,胡传飞,王思宇,刘红玲..支气管动脉灌注化疗联合信迪利单抗序贯根治性放疗治疗大肿块Ⅲ期鳞状非小细胞肺癌:一项单中心、单臂研究[J].转化医学杂志,2025,14(1):105-111,7.基金项目
国家抗肿瘤药物临床应用监测网2022-2023年度肿瘤规范化诊疗中青年研究基金资助课题(DSS-MR-2023018) （DSS-MR-2023018）
2024年四川省卫生健康委员会科技项目(第一批)(24WSXT074) （第一批）
院级科研课题(2022-KYY-08) （2022-KYY-08）
