中药药理与临床2025，Vol.41Issue(4)：95-99,5.
基于中西医临床病证特点的代谢综合征动物模型分析
Animal Models of Metabolic Syndrome Based on Disease-Syndrome Characteristics in Traditional Chinese and Western Medicine
摘要
Abstract
Objective:With the improvement of quality of life,the onset of metabolic syndrome is becoming more and more common,which seriously affects people's life and health.Through in-depth analysis and investigation of this disease,this study aimed to provide some references for clinical diagnosis and treatment and facilitate the research on clinical prevention and treatment.Methods:This paper analyzed the clinical consistency of the corresponding animal models and summarized their modeling methods and model characteristics based on the clinical diag-nostic criteria of traditional Chinese and western medicine for metabolic syndrome.Results:The main existing animal models are diet-induced models,diet combined with drug-induced models,and genetic models.Among these animal models,the diet combined with drug-induced ani-mal models are closer to human pathogenesis and widely used,with the highest clinical consistency.Conclusion:The above-mentioned model-ing methods are mostly based on western medicine etiology and pathogenesis,and there are fewer models related to syndrome in TCM.In fu-ture research,more animal models related to syndrome in TCM should be actively developed,so that animal models can be closer to clinical practice to promote in-depth research and provide a theoretical basis for clinical TCM treatment.关键词
病证结合/代谢综合征/动物模型Key words
Disease-syndrome ccombination/Metabolic syndrome/Animal model引用本文复制引用
杜方绵,王赛,谢逸轩,白莉,苗明三..基于中西医临床病证特点的代谢综合征动物模型分析[J].中药药理与临床,2025,41(4):95-99,5.基金项目
国家自然科学基金(编号:80274038) （编号:80274038）
河南省重大公益专项(编号:201300310100) （编号:201300310100）
河南省药品监督管理局科技计划项目(编号:2020DB050-55、2020DB134-49) （编号:2020DB050-55、2020DB134-49）
国家重大新药创制(编号:2017ZX09301071) （编号:2017ZX09301071）
河南省高等学校青年骨干教师培养计划项目(编号:2020GGJS110). （编号:2020GGJS110）
