转化医学杂志2025，Vol.14Issue(3)：116-122,7.DOI:10.3639/j.issn.2095-3097.2025.03.022
TRPM2-Hh与前列腺癌患者预后和免疫浸润的相关性研究
Study on the Correlation between TRPM2-Hh and the Prognosis and Immune Infiltration of Prostate Cancer Patients
摘要
Abstract
Objective To explore the expression of transient receptor potential melastatin 2(TRPM2)in prostate can-cer and its correlation with the prognosis and immune infiltration.Methods The TIMER database was used to investigate the expression levels of TRPM2 between prostate cancer tumors and adjacent normal tissues.The prognostic value of TRPM2 ex-pression levels was evaluated;the expression levels of the TRPM2 gene under different mutation states of prostate cancer sus-ceptibility genes was assessed;the correlation between TRPM2 expression and the tumor microenvironment in prostate cancer was analyzed.The expression level of TRPM2 mRNA in prostate cancer tissues was verified by RT-qPCR.The expression levels of prostate-specific antigen(PSA)and TRPM2 protein in prostate cancer plasma,as well as the correlation between them,were verified by ELISA.The expression level of TRPM2 protein in the plasma of patients with prostate cancer before and after surgery was verified by ELISA.Results The expression level of TRPM2 in prostate cancer tissues was significantly higher than that in the corresponding adjacent tissues;there was no significant correlation between TRPM2 expression level and the poor prognosis of prostate cancer patients;the expression level of TRPM2 had a certain correlation with prostate cancer susceptibility genes.TRPM2 expression was positively correlated with the infiltration of regulatory T cells,non-regulatory CD4+T cells,CD8+T cells,B cells,NK cells,neutrophils,monocytes,cancer-associated fibroblasts,macrophages,endothelial cells,and dendritic cells,and negatively correlated with the infiltration of mast cells and CD4+T cells.The mRNA expression of TRPM2 in prostate cancer was significantly higher than that in the corresponding adjacent tissues(P<0.001);the expression levels of PSA and TRPM2 in pros-tate cancer plasma were positively correlated with the tumor clinical stage(P<0.001),and there was a certain correlation between PSA and TRPM2.The expression level of TRPM2 in the plasma of prostate cancer patients after surgery was significantly lower than that before surgery(P<0.001).Conclusion TRPM2 is highly expressed in prostate cancer,shows no significant correlation with the poor prognosis of prostate cancer patients,is related to prostate cancer susceptibility genes and prostate cancer immune infiltration,and is a potential prognostic biomarker and immune target.关键词
前列腺癌/免疫浸润/预后/生物标志物Key words
Prostate cancer/Immune infiltration/Prognosis/Biomarker分类
医药卫生引用本文复制引用
孙强,鲁洪泽,毕明星,刘健..TRPM2-Hh与前列腺癌患者预后和免疫浸润的相关性研究[J].转化医学杂志,2025,14(3):116-122,7.基金项目
河北省医学科学研究课题(20211167) （20211167）
