中药药理与临床2025，Vol.41Issue(4)：118-124,7.
斑马鱼内毒素炎症模型及相关复方、中药及活性成分研究进展
Advances in Zebrafish Models of Endotoxin-Induced Inflammation and Treatment with Traditional Chinese Medicine
摘要
Abstract
Inflammation is the pathological foundation for numerous diseases,rendering the exploration of novel therapeutic agents for its treatment a persistent focus in related scientific disciplines.Traditional Chinese medicine(TCM)holds distinct advantages in the management of inflam-matory conditions.Nevertheless,the intricate composition of TCM compound prescriptions,encompassing diverse effective components and ac-tive ingredients,poses challenges in their comprehensive understanding.The absence of animal models for efficient and reliable in vivo high-throughput screening and mechanism research has hindered progress in this domain.Zebrafish have emerged as a valuable tool due to the im-munological similarities to humans,cost-effectiveness,ease of observation,and amenability to genetic manipulation.The zebrafish model of en-dotoxin-induced inflammation has been maturely employed for the assessment of anti-inflammatory drug activity and the exploration of underly-ing mechanisms.This paper provides a concise overview of the advances in the zebrafish model of endotoxin-induced inflammation and the re-search on treatment of inflammation with TCM.It is expected to facilitate further utilization of this model and to inform the future research on the TCM treatment of inflammation.关键词
中药/炎症/斑马鱼/斑马鱼内毒素炎症模型Key words
Traditional Chinese medicine/Inflammation/Zebrafish/Zebrafish model of endotoxin-induced inflammation引用本文复制引用
何彭可,区锦莹,余林中,卢子滨..斑马鱼内毒素炎症模型及相关复方、中药及活性成分研究进展[J].中药药理与临床,2025,41(4):118-124,7.基金项目
广东省基础与应用基础研究基金(面上项目)(编号:2023A1515011106) （面上项目）
广州市科技计划项目-基础研究计划-基础与应用基础研究专题(编号:2023A04J1825). （编号:2023A04J1825）
