中国肿瘤外科杂志2025，Vol.17Issue(2)：146-151,6.DOI:10.3969/j.issn.1674-4136.2025.02.008
CHST11、CHST15 在胰腺导管腺癌组织的表达及其与预后的关系分析
Analysis of the relationship between the expression of CHST11 and CHST15 in pancreatic ductal adenocarcinoma tissues and prognosis
摘要
Abstract
Objective To investigate the relationship between the expression of carbohydrate sulfotransferase 11(CHST11)and carbohydrate sulfotransferase 15(CHST15)in pancreatic ductal adenocarcinoma(PDAC)tissues and prognosis.Methods A total of 139 patients with PDAC diagnosed and treated in Handan Central Hospital from January 2019 to December 2020 were selected,and the cancer tissues and adjacent normal tissues were collected.The positive expression rates of CHST11 and CHST15 proteins in PDAC tissues and adjacent normal tissues were detected and compared by immunohistochemistry.The relationship between the positive expression rates of CHST11 and CHST15 proteins and the clinicopathological features of PDAC patients was analyzed.The 3-year cumulative survival rate in CHST11 and CHST15 positive expression group and negative expression group were analyzed by Kaplan-Meier method.The prognostic factors of PDAC patients were analyzed by univariate and multivariate COX proportional hazard models.Results Compared to adjacent normal tissues,the positive expression rates of CHST11 and CHST15 proteins in PDAC tissues were significantly increased(P＜0.05).The positive expression rates of CHST11 and CHST15 in patients with TNM stage Ⅲ,lymph node metastasis and nerve invasion were significantly higher than those in patients with TNM stageⅠ+Ⅱ,no lymph node metastasis and nerve invasion(P＜0.05).Two cases were lost to follow-up among the 139 PDAC patients during the 3-year follow-up period,and 137 were successfully followed up,the overall survival rate was 14.60%(20/137).The Kplan-Meier survival curve showed that the 3-year cumulative survival rate in CHST11 positive expression group[9.52%(8/84)]was significantly lower than that in CHST11 negative expression group[22.64%(12/53)],and the 3-year cumulative survival rate in CHST15 positive expression group[11.34%(11/97)]was significantly lower than that in CHST15 negative expression group[22.50%(9/40)](all P＜0.05).Cox regression analysis showed that positive expression of CHST11,lymph node metastasis,nerve invasion,positive expression of CHST15,TNM stage Ⅲ,and postoperative adjuvant chemotherapy were risk factors for PDAC prognosis(P＜0.05).Conclusions The positive rates of CHST11 and CHST15 proteins in PDAC tissues are increased,which is related to TNM stageⅢ,lymph node metastasis,nerve invasion,and poor prognosis.关键词
碳水化合物磺基转移酶 11/碳水化合物磺基转移酶 15/胰腺导管腺癌/病理特征/预后Key words
Carbohydrate sulfotransferase 11/Carbohydrate sulfotransferase 15/Pancreatic ductal adenocarcinoma/Pathological features/Prognosis引用本文复制引用
尹立阳,安睿嘉,霍浩然,薛佳栋,郝亚静,袁增江,李慎..CHST11、CHST15 在胰腺导管腺癌组织的表达及其与预后的关系分析[J].中国肿瘤外科杂志,2025,17(2):146-151,6.基金项目
河北省卫生健康委2019年度医学科学研究课题计划(20190199) （20190199）
