中国中医药信息杂志2025，Vol.32Issue(4)：14-18,5.DOI:10.19879/j.cnki.1005-5304.202403037
基于内皮细胞衰老探讨从肾论治冠心病的生物学内涵
Exploration on the Biological Connotation of Treating Coronary Heart Disease from Kidney Based on Endothelial Cell Aging
摘要
Abstract
Coronary heart disease has a significant age correlation,and cell aging is the basic factor of aging of the body.Aging endothelial cells can interfere with the development of coronary heart disease through oxidative stress,mitochondrial dysfunction and other ways.This article focused on the mechanism of endothelial cell aging promoting coronary heart disease,which is related to"kidney"in TCM.Kidney has physiological characteristics such as participating in the growth and aging,the interaction of essence and blood,water and liquid metabolism,etc.Deficiency of kidney essence can slow down the generation of kidney turbidity,which can also be followed by blood stasis,phlegm and other pathogenic factors eroding arteries,which is consistent with the role of endothelial cell aging in promoting plaque development and accelerating thrombosis.The article also discussed the biological connotation of treating coronary heart disease from kidney from the perspective of endothelial cell aging,and put forward that the basic principle of treating coronary heart disease from kidney should be tonifying kidney and expelling turbidity,and then treat it according to different syndromes such as heart-kidney disharmony,qi stagnation in the heart and chest,phlegm obstruction in collaterals and blood stasis obstruction in collaterals,providing new ideas for the biological research and clinical application of TCM in the treatment of coronary heart disease.关键词
细胞衰老/内皮细胞/肾痰/从肾论治/动脉粥样硬化/冠心病Key words
cell senescence/endothelial cells/kidney phlegm/treating from kidney/atherosclerosis/coronary heart disease分类
医药卫生引用本文复制引用
胡伊蕾,蔡磊,马至言,罗晓欣,简维雄..基于内皮细胞衰老探讨从肾论治冠心病的生物学内涵[J].中国中医药信息杂志,2025,32(4):14-18,5.基金项目
国家自然科学基金面上项目(81973753) （81973753）
湖南省自然科学基金(2022JJ30433) （2022JJ30433）
湖南省研究生科研创新项目(CX20220781) （CX20220781）
