中国猪业2025，Vol.20Issue(2)：15-22,8.DOI:10.16174/j.issn.1673-4645.2025.02.002
基因编辑猪的遗传改良与生物医学应用:技术潜力与现实挑战
Genetic Modification and Biomedical Applications of Genetically Modified Pigs:Technical Potential and Practical Challenges
摘要
Abstract
Gene editing technology had demonstrated significant potential in the genetic improvement of pigs and biomedical research.Gene-edited pigs has exhibited good production traits and disease resistance,which could increase breeding income.Due to their closer resemblance to humans in anatomical structure,metabolism,and physiological-biochemical characteristics compared to ro-dents,pigs served as ideal disease models and xenotransplantation organ donors.However,gene-edited pigs also faced multiple challenges,including the need to improve the efficiency and accuracy of gene editing,as well as addressing off-target effects that might lead to unintended genetic alterations.Additionally,divergent regulatory policies across regions pose obstacled to the industrial-ization and commercialization of gene-edited pigs.A comprehensive understanding of the current status and challenges of gene-edit-ed pigs would facilitate their rational development in scientific research and practical applications.关键词
猪/基因编辑/异种器官移植/CRISPR/Cas9/遗传改良/代谢/生理Key words
pig/gene editing/xenotransplantation/CRISPR/Cas9/genetic improvement/metabolism/physiology分类
畜牧业引用本文复制引用
王文娜,齐世宏,余大为,黄永业..基因编辑猪的遗传改良与生物医学应用:技术潜力与现实挑战[J].中国猪业,2025,20(2):15-22,8.基金项目
国家自然科学基金(81502582) （81502582）
