中国猪业2025，Vol.20Issue(2)：51-62,12.DOI:10.16174/j.issn.1673-4645.2025.02.005
猪肾在生物医学中的应用
Application of Pig Kidney in Biomedicine
摘要
Abstract
Porcine kidney was widely used in biomedical research because of its similarity to human kidney,and its anatomical structure and physiological characteristics made it an ideal disease model.In the exploration of disease mechanisms,porcine kidney had been widely used to construct pathological models of acute and chronic renal failure,diabetic nephropathy,hypertensive nephropathy,and ischemia-reperfusion injury,provided a key platform for revealing the molecular mechanisms of renal fibrosis,inflammatory response,and metabolic imbalance.In addition,it demonstrated unique advantages in evaluating new therapeutic options and promoting drug development,especially in drug metabolism and renal function assessment.Meanwhile,porcine kidneys also had great potential in xenotransplantation,and the application of gene editing techniques such as CRISPR/Cas9 could help to minimize rejection,thus provid-ed a new direction to solve the organ shortage problem.However,future research still needed to address immune rejection and ethical issues to advance its development in clinical applications.Overall,porcine kidney had great potential in biomedicine and opens new pathways for treatment and research of related diseases.关键词
猪/肾脏/生物医学/疾病模型/基因编辑/异种移植/免疫排斥Key words
pigs/kidney/biomedical science/disease model/gene editing/xenotransplantation/immune rejection分类
畜牧业引用本文复制引用
骆庆龙,练胜举,王婧,龙次民,刘梅..猪肾在生物医学中的应用[J].中国猪业,2025,20(2):51-62,12.基金项目
湖南省重点研发计划项目(2023DK2004) （2023DK2004）
