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Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis

Li Yuan Chao Gao Shisuo Du Yue Wang Junjie Cheng Shilin Lin Aying Ma Kunchao Li Yiming Zheng Zhaochong Zeng Aiwu Ke

癌症生物学与医学（英文版）2025，Vol.22Issue(4)：396-411,16.

癌症生物学与医学（英文版）2025，Vol.22Issue(4)：396-411,16.DOI:10.20892/j.issn.2095-3941.2024.0544

Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis

Li Yuan ¹Chao Gao ¹Shisuo Du ²Yue Wang ¹Junjie Cheng ³Shilin Lin ¹Aying Ma ¹Kunchao Li ⁴Yiming Zheng ¹Zhaochong Zeng ²Aiwu Ke¹

作者信息

1. Liver Cancer Institute,Zhongshan Hospital,Fudan University,Key Laboratory of Carcinogenesis and Cancer Invasion(Fudan University),Ministry of Education,Shanghai 200032,China
2. Department of Radiation Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China
3. Graduate School of Bengbu Medical University,Bengbu 233030,China
4. Department of Cardiovascular Surgery,The Second Affiliated Hospital of Nanchang University,Nanchang 330000,China
折叠

摘要

关键词

circTMEM56/hepatocellular carcinoma/cGAS-STING/radiotherapy/dendritic cell

Key words

circTMEM56/hepatocellular carcinoma/cGAS-STING/radiotherapy/dendritic cell

引用本文复制引用

Li Yuan,Chao Gao,Shisuo Du,Yue Wang,Junjie Cheng,Shilin Lin,Aying Ma,Kunchao Li,Yiming Zheng,Zhaochong Zeng,Aiwu Ke..Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis[J].癌症生物学与医学（英文版）,2025,22(4):396-411,16.

基金项目

This study was funded by the National Key Research and Development Program of China(Grant No.2023YFC3402700),Shanghai Municipal Natural Science Foundation(Grant No.22ZR1411200),China Postdoctoral Science Fund-General Fund(Grant No.2022M720779),Research Fund of Zhongshan Hospital Affiliated to Shanghai Fudan University for Young Scientists(Grant No.2023ZSQN26),and National Natural Science Foundation of China(Grant Nos.82403999 and 82073479). （Grant No.2023YFC3402700）

癌症生物学与医学（英文版）

ISSN：2095-3941

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