中国肿瘤生物治疗杂志2025，Vol.32Issue(3)：301-308,8.DOI:10.3872/j.issn.1007-385x.2025.03.010
宫颈产生黏液复层上皮肿瘤性病变的临床组织及分子病理特征
Stratified mucin-producing epithelial neoplastic lesions of the cervix:clinicohistologic and molecular pathological characteristics
摘要
Abstract
Objective:To investigate the clinicohistologic and molecular pathological characteristics of invasive stratified mucin-producing carcinoma(ISMC).Methods:The clinicopathological data,immunohistochemistry,alcian blue/periodic acid-Schiff(AB/PAS)staining,molecular detection and PD-L1 expressions of 11 cases of ISMC and 4 cases of stratified mucin-producing intraepithelial lesion(SMILE)in the pathological database of Anqing Medical Center of Anhui Medical University/Anqing Municipal Hospital and the first Affiliated hospital of Wannan Medical School/Yijishan Hostital between January of 2018 and March of 2024 were retrospectively analyzed.Results:ISMC patients often presented with irregular vaginal bleeding.Morphologically,the cells containing mucus in the cytoplasm were arranged in stratified layers,surrounded by a palisade,and the tumor cells might be signet ring-shaped or have clear cytoplasm.ISMC might occur in both pure and mixed forms.ISMC had highly invasive biological characteristics.CK7,p16,p40 and(or)p63 were expressed focally or positively in the form of palisades around the cancer nests.AB-PAS staining was positive.HPV test results:HPV16/18 was positive in ISMC(1/4);HPV16/18 was positive before surgery(4/6);no HPV was detected in SMILE;all ISMC cases expressed PD-L1.Eight ISMC patients were successfully followed up for 4-39 months(average 20.50 months),and four SMILE patients for 1-25 months(average 8.25 months).All followed-up patients survived;however,one ISMC patient developed multi-organ metastases post-surgery.Conclusion:ISMC has unique morphological characteristics and immunophenotypes,indicated by high invasiveness and poor prognosis.All ISMC are PD-L1 positive,suggesting that these patients may benefit from PD-L1 immunotherapy.关键词
宫颈/浸润性复层产生黏液的复层上皮癌(ISMC)/产生黏液的复层上皮内病变(SMILE)/临床病理/程序性死亡受体配体-1(PD-L1)/人乳头状瘤病毒(HPV)Key words
cervix/invasive stratified mucin-producing carcinoma(ISMC)/stratified mucin-producing intraepithelial lesion(SIMLE)/clinicopathology/programmed death-ligand 1(PD-L1)/human papilloma virus(HPV)分类
医药卫生引用本文复制引用
刘雅玲,黄献,王菲,胡泉泉,宣兰兰..宫颈产生黏液复层上皮肿瘤性病变的临床组织及分子病理特征[J].中国肿瘤生物治疗杂志,2025,32(3):301-308,8.基金项目
安庆市2023年度医疗卫生类自筹经费科技计划项目(No.2023Z1002) （No.2023Z1002）
