中西医结合肝病杂志2025，Vol.35Issue(4)：402-405,4.DOI:10.3969/j.issn.1005-0264.2025.004.002
铂类化疗药物诱发门静脉肝窦血管性疾病1例及文献复习
Porto-sinusoidal vascular disorder induced by platinum-based chemotherapeutic drugs:a case report and literature review
何承志 1夏璐 1王喆 1杨长青1
作者信息
- 1. 同济大学附属同济医院消化科(上海,200065)
- 折叠
摘要
Abstract
Drug-induced liver injury(DILI)caused by platinum-based chemotherapy drugs is characterized by elevated aminotransferase,while vascular injury is relatively rare as a special clinical phenotype of DILI.It has been reported that DILI caused by platinum-based chemotherapy drugs is more common with hepatic sinus obstruction syndrome,while porto-sinusoidal vascular disorder(PSVD)caused by platinum-based chemotherapy drugs is rarely reported.This report describes a case with prominent clinical manifestations of portal hypertension and normal or nearly normal liver function.Liver function impairment and portal hypertension were not parallel.Extrahepatic vascular diseases were excluded by imaging.Although imaging suggested cirrhosis,liver transient elastography(TE)did not support cirrhosis,and liver biopsy histopathology also excluded cirrhosis,revealing characteristic histopathological features of PSVD.The patient was diagnosed with PSVD induced by platinum-based chemotherapy drugs.After one year of follow-up,the patient's condition remained relatively stable.关键词
门脉高压/食管胃底静脉曲张/肝脏血管性疾病/门脉肝窦血管病Key words
portal hypertension/esophageal and gastric varices/vascular disease of the liver/portal-sinusoidal vascular disorder分类
医药卫生引用本文复制引用
何承志,夏璐,王喆,杨长青..铂类化疗药物诱发门静脉肝窦血管性疾病1例及文献复习[J].中西医结合肝病杂志,2025,35(4):402-405,4.
