中西医结合肝病杂志2025，Vol.35Issue(4)：410-414,5.DOI:10.3969/j.issn.1005-0264.2025.004.004
非酒精性脂肪性肝病患者菌群多样性及其与肝纤维化相关细胞因子的相关性
Bacterial diversity in patients with nonalcoholic fatty liver disease and its association with liver fibrosis-related cytokines
摘要
Abstract
Objective:Exploring the diversity of the microbiota in patients with nonalcoholic fatty liver disease(NAFLD)and its correlation with liver fibrosis-related cytokines.Methods:A total of 137 patients with NAFLD treated in our hospital from January 2023 to December 2023 were selected as the NAFLD group,and 109 patients with healthy results in our hospital during the same period were selected as the control group.Stool samples were collected from all patients for analysis and comparison of intestinal flora,while fasting venous blood was collected for detection and comparison of liver fibrosis-related cytokines interleukin1 β,6,12,17,21,32(IL-1β,IL-12,IL-17,IL-21,IL-32)and tumor necrosis factor α(TNF-α).Finally,the correlation between intestinal flora diversity and liver fibrosis related factors in NAFLD patients was analyzed.Results:IL-1 β,IL-12,IL-17,IL-21,IL-32 and TNF-α in NAFLD group were significantly higher than those in control group,with statistical significance(P＜0.05).Chao1 index,ACE index and Shannon index in NAFLD group were lower than those in control group,while Simpson index was higher than those in control group,with statistical significance(P＜0.05).In the control group,Parabacteroides,Lactobacillus,Prevotella,Bifidobacterium,Flavobacterium and Oscillibacter had high abundance and were the main dominant bacteria.In the intestinal flora of NAFLD group,Bacteroides,Clostridiun_butyricum,Escherichia,Clostridiun_leptum,Enterobacteriaceae,Bacteroidetes,Eubacteriun,Streptococcus have a high abundance and are the main dominant bacteria.Parabacteroides,Lactobacillus,Prevotella,Bifidobacterium and Oscillibacter were negatively correlated with liver fibrosis-related cytokines.Bacteroides,Clostridiun_butyricum,Escherichia and Bacteroidetes were positively correlated with liver fibrosis related cytokines(P＜0.05).Conclusion:Patients with NAFLD have significant abnormalities in the diversity of intestinal microflora and correlate with liver fibrosis-related cytokines.关键词
非酒精性脂肪性肝病/肠道菌群/肝纤维化/细胞因子Key words
nonalcoholic fatty liver disease/intestinal flora/liver fibrosis/cytokine分类
医药卫生引用本文复制引用
王娜,代琴棋..非酒精性脂肪性肝病患者菌群多样性及其与肝纤维化相关细胞因子的相关性[J].中西医结合肝病杂志,2025,35(4):410-414,5.基金项目
新疆医科大学第七附属医院院内科研基金(No.YZR2021-03) （No.YZR2021-03）
