中西医结合肝病杂志2025，Vol.35Issue(4)：415-419,5.DOI:10.3969/j.issn.1005-0264.2025.004.005
基于"土壅木郁"理论探析人体成分及肝功能等指标对代谢相关脂肪性肝病中医证型的评估价值
Evaluation of body composition and liver function indicators in assessing traditional Chinese medicine syndromes in metabolic associated fatty liver disease based on the theory of"soil impediment and wood stagnation"
摘要
Abstract
Objective:This study,based on the theory of"soil impediment and wood stagnation,"explores the value of body composition and liver function indicators in assessing traditional Chinese medicine(TCM)syndromes in metabolic associated fatty liver disease(MAFLD).Methods:118 patients with MAFLD who first visited the Obesity Clinic at Hubei Provincial Hospital of Traditional Chinese Medicine between June and December 2022 were included in the study.The levels of body mass index(BMI),basal metabolic rate(BMR),visceral fat area(VFA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil),direct bilirubin(DBil),hypersensitive C reactive protein(hs-CRP)and controlled decay parameter(CAP)were compared in four syndrome types:liver-depression and spleen-deficiency,phlegm-turbidity internal obstruction,dampness-heat accumulation and phlegm-blood stasis interconnection.Multivariate disordered multiple Logistic regression was used to analyze the predictors of TCM syndrome types in MAFLD patients.Results:There were 40 cases(34.0％)in the liver-depression and spleen-deficiency group,24 cases(20.3％)in the phlegm-turbidity internal obstruction group,34 cases(28.8％)in the dampness-heat accumulation group,and 20 cases(16.9％)in the phlegm-blood stasis interconnection group.The levels of BMR,TBil and DBil were significantly different(P＜0.05)in four groups.The results of disordered multiple Logistic regression showed that TBil was the predictor of phlegm turbidity obstruction syndrome(OR=1.27,95％CI:1.032-1.565,P=0.024),taking liver-stagnation and splee-deficiency syndrome as reference.The variables were not statistically significant in the phlegm-turbidity internal obstruction syndrome group,ddampness-heat accumulation syndrome group,and phlegm-blood stasis interconnection syndrome group as reference(P＞0.05).Conclusion:MAFLD patients with different TCM syndromes exhibit differences in BMR,TBil,and DBil levels.TBil is higher in the phlegm-damp obstruction syndrome group compared to the liver-stagnation and splee-deficiency syndrome group.TBil is a promising predictive factor for TCM syndromes in MAFLD and warrants further research.关键词
代谢相关脂肪性肝病/土壅木郁/中医证型/人体成分分析/肝功能Key words
metabolic associated fatty liver disease/soil obstructed and wood obstructed/TCM syndrome/body composition analysis/liver function分类
医药卫生引用本文复制引用
张椿枚,高小莲,王景芝,肖明中,陶军秀..基于"土壅木郁"理论探析人体成分及肝功能等指标对代谢相关脂肪性肝病中医证型的评估价值[J].中西医结合肝病杂志,2025,35(4):415-419,5.基金项目
湖北省自然科学基金项目(No.2023AFD178) （No.2023AFD178）
