摘要
Abstract
Objective:To observe the curative effect of pegylated interferon(Peg IFN)α-2b in the treatment of chronic hepatitis B patients with abnormal alanine aminotransferase(ALT)after nucleotide analogues(NAs)treatment,and to provide reference for clinical treatment.Methods:Chronic hepatitis B patients treated with NAs for more than 4 years and with abnormal ALT were included in the control group and the combination group from January 2021 to March 2022.According to China's"Chronic Hepatitis B Prevention and Treatment Guidelines(2022 edition)",the control group continued to receive NAs,the combined group was treated with Peg IFN α-2b.Other liver function indexes such as ALT,hepatitis B surface antigen content and hepatitis B DNA quantitative determination(take the qualitative result as a decision statistical value)were observed in the two groups,and adverse drug reactions were monitored.After 48 weeks of treatment,the combination group was switched to single NAs treatment regardless of outcome,and follow-up was conducted for 1 year.Results:A total of 86 patients were included,31 patients in the control group and 55 patients in the combination group.There was no statistically significant difference in baseline levels between the two groups.After 24 weeks of treatment,the content of hepatitis B virus surface antigen and the normal rate of ALT in combination group were better than those in control group(P＜0.05).After 48 weeks of treatment,the negative rate of hepatitis B virus surface antigen,the normal ALT,and the negative rate of hepatitis B virus DNA in combination group were better than those in control group(P＜0.05).After 1 year of follow-up,the content of hepatitis B virus surface antigen,normal rate of ALT,negative rate of hepatitis B virus surface antigen,negative rate of hepatitis B virus DNA in combination group were better than those in control group(P＜0.05).Five patients in the combination group had adverse drug reactions during combination therapy and were given Peg IFN α-2b intermittenously.Eleven patients persisted in treatment due to minor adverse drug reactions.Conclusion:Although there is a certain proportion of controllable adverse drug reactions,combined Peg INF α-2b therapy can improve the clinical efficacy of chronic hepatitis B patients with abnormal ALT after treatment with NAs.关键词
丙氨酸氨基转移酶/慢性乙型肝炎/核苷酸类似物/聚乙二醇干扰素α-2b/药物不良反应Key words
alanine aminotransferase/chronic hepatitis B/nucleotide analogues/pegylated interferon α-2b/adverse drug reaction分类
医药卫生
