中西医结合肝病杂志2025，Vol.35Issue(4)：425-429,5.DOI:10.3969/j.issn.1005-0264.2025.004.007
血清Eotaxin、NGAL、SAA对乙型肝炎肝硬化输血不良反应的预测价值
Predictive value of serum eotaxin,neutrophil gelatinase-associated lipocalin,and serum amyloid A for adverse transfusion reactions in hepatitis B cirrhosis
摘要
Abstract
Objective:To explore the predictive value of serum eosinophil chemotactic factor(Eotaxin),neutrophil gelatinase-associated lipocalin(NGAL)and serum amyloid A(SAA)on adverse transfusion reactions in hepatitis B cirrhosis.Methods:A total of 80 hepatitis B cirrhosis patients who received blood transfusion treatment in our hospital from March 2021 to June 2023 were included.Of these,39 patients who experienced adverse reactions were in the observation group,and 41 patients who did not experience adverse reactions were in the control group.Enzymelinked immunosorbent assay(ELISA)was used to detect serum levels of Eotaxin,NGAL,and SAA.Clinical data were collected,and multivariate logistic regression was applied to analyze factors influencing adverse transfusion reactions.Receiver Operating Characteristic(ROC)curve analysis was performed to assess the predictive value of serum Eotaxin,NGAL,and SAA in adverse transfusion reactions.Results:After blood transfusion,the serum levels of Eotaxin,NGAL and SAA in the observation group were higher than those in the control group(P＜0.05).Clinical data comparison found that there were differences in the number of blood transfusions,time from onset to transfusion,history of previous blood transfusions,and history of allergies between the two groups(P＜0.05),and the number of blood transfusions,time from onset to transfusion,previous transfusion history,allergy history,serum Eotaxin,NGAL and SAA levels were all factors that affected the occurrence of transfusion adverse reactions in hepatitis B cirrhosis(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum Eotaxin,NGAL,SAA and their combination in predicting adverse transfusion reactions in hepatitis B cirrhosis was 0.891,0.736,0.877 and 0.969,respectively,the combined predictive value of these three factors was higher than that of single prediction(Z the combination-Eotaxin=2.264,Z the combination-NGAL=4.215,Z the combination-SAA=2.768,P＜0.05).Conclusion:Serum Eotaxin,NGAL,and SAA levels are elevated in hepatitis B cirrhosis with adverse transfusion reactions,and the combination of these three factors has predictive value for adverse transfusion reactions.关键词
乙型肝炎肝硬化/输血不良反应/血清嗜酸性粒细胞趋化因子/中性粒细胞明胶酶相关脂质运载蛋白/血清淀粉样蛋白Key words
Hepatitis B cirrhosis/adverse transfusion reactions/serum eosinophil chemotactic factor/neutrophil gelatinase-associated lipocalin/serum amyloid A分类
医药卫生引用本文复制引用
李双,李超,李英..血清Eotaxin、NGAL、SAA对乙型肝炎肝硬化输血不良反应的预测价值[J].中西医结合肝病杂志,2025,35(4):425-429,5.基金项目
河北省卫生健康委员会(No.20220003) （No.20220003）
