中国现代医生2025，Vol.63Issue(12)：1-4,48,5.DOI:10.3969/j.issn.1673-9701.2025.12.001
膝骨关节炎用药特点的古代数据挖掘
Ancient data mining on drug characteristics of knee osteoarthritis
摘要
Abstract
Objective To analyze ancient prescriptions for knee osteoarthritis(KOA),and explore their application patterns,for providing clinical reference value.Methods Prescriptions were collected from ancient documents,and a database was created by using Excel 2016 for frequency analysis.Association rules and hidden structures were analyzed by using SPSS Modeler 18.0 and Lantern 5.0.Results A total of 373 prescriptions and 421 herbs were collected,with 3894 times of frequency of medication.Danggui was the most frequently used herb.Herbs primarily tonified deficiencies,relieved exterior symptoms,and expelled wind-dampness,with warm properties and pungent,sweet,or bitter tastes,mainly targeting the spleen and kidney meridians.Thirteen strong association rules were identified,including Chuanxiong+Niuxi-Danggui,and Bixie-Niuxi.Hidden structure analysis revealed 10 variables,leading to 4 clusters and 4 core prescriptions.Common syndromes included wind-damp,wind-cold-damp,wind-damp-heat,and qi-blood deficiency.Conclusion The treatment of KOA in ancient literature focuses on dispelling wind and removing dampness,taking into account both positive deficiency and evil excess,flexible use of tonifying spleen and kidney,clearing dampness-heat,tonifying Qi and blood and other drugs.关键词
膝骨关节炎/隐结构/关联规则分析/用药规律Key words
Knee osteoarthritis/Latent structure/Association rule analysis/Medication law分类
医药卫生引用本文复制引用
孟梓涵,赵合立,虞跃跃,史晓燚,马欣宇,武叮叮,张旭,李贺祎,王静雅,张莉苑..膝骨关节炎用药特点的古代数据挖掘[J].中国现代医生,2025,63(12):1-4,48,5.基金项目
国家级大学生创新训练项目(202310081043) （202310081043）
