中国现代医生2025，Vol.63Issue(12)：10-13,121,5.DOI:10.3969/j.issn.1673-9701.2025.12.003
基于肠道菌群培养及鉴定技术探讨肠道菌群变化与老年慢性肾衰竭的相关性
Exploring the correlation between gut microbiota changes and chronic renal failure in the elderly based on gut microbiota cultivation and identification techniques
摘要
Abstract
Objective To explore the correlation between changes in gut microbiota and the occurrence of chronic renal failure(CRF)in elderly patients,providing theoretical evidence for the prevention and treatment of CRF in the elderly.Methods A total of 57 elderly patients with CRF admitted to Department of Nephrology,Jilin People's Hospital from June 2021 to June 2023 were selected as observation group,while 65 healthy individuals who underwent physical examinations at the same hospital during the same period were chosen as control group.Baseline data,gut microbiota composition,and biochemical indicators were compared between two groups.Results The levels of γ-glutamyl transferase,creatinine,urea,uric acid,N-terminal pro-brain natriuretic peptide,parathyroid hormone,hypersensitive C-reactive protein,and serum phosphorus were higher in observation group than those in control group,whereas serum calcium was lower;all differences were statistically significant(P＜0.05).Firmicutes and Bacteroidetes were dominant in two groups,accounting for 49.22％and 43.12％in observation group and 49.47％and 42.01％in control group,respectively.At the genus level,Bacteroides predominated,comprising 8.69％and 9.68％of the total,respectively.Multivariate Logistic regression analysis showed that Actinobacteria(95％CI:0.015-0.391,P=0.002),Lactobacillus(95％CI:0.224-0.577,P＜0.001),Bifidobacterium(95％CI:0.150-0.933,P=0.035),and Streptococcus(95％CI:0.256-0.687,P-0.001)were negatively associated with the occurrence of CRF in the elderly,whereas Clostridium(95％CI:2.176-15.047,P＜0.001)and Enterococcus(95％CI:1.579-7.224,P=0.002)were positively associated.Conclusion Changes in gut microbiota are closely related to the development of CRF in the elderly.Clinically,attention should be paid to the cultivation and identification of gut microbiota in this population,in order to provide guidance for the diagnosis and treatment of intestinal flora disorders in patients with CRF,guide probiotic application,and formulate microecological regulation programs.关键词
慢性肾衰竭/肠道菌群/老年人/培养/鉴定Key words
Chronic renal failure/Gut microbiota/Elderly/Cultivation/Identification分类
临床医学引用本文复制引用
马玉杰,鲁新,房若文..基于肠道菌群培养及鉴定技术探讨肠道菌群变化与老年慢性肾衰竭的相关性[J].中国现代医生,2025,63(12):10-13,121,5.基金项目
吉林省卫生健康科技能力提升项目(2021LC121) （2021LC121）
