中国现代医生2025，Vol.63Issue(12)：19-24,52,7.DOI:10.3969/j.issn.1673-9701.2025.12.005
原发性神经内分泌前列腺癌的临床特征及预后分析
Clinical characteristics and prognostic analysis of primary neuroendocrine prostate cancer
摘要
Abstract
Objective To analyze the clinical characteristics of primary neuroendocrine prostate cancer(NEPC)and its impact on patient survival.Methods A retrospective analysis was conducted by using clinical data from 437 865 prostate cancer patients extracted from the SEER database.Based on histopathology,patients were categorized into prostate adenocarcinoma(AD)group and NEPC group.Propensity score matching was employed to reduce selection bias.Clinical characteristics between two groups were compared by using the Kruskal-Wallis test and Pearson x2 test,and multicollinearity was assessed for prognostic variables.The Fine-Gray competing risk regression model and cumulative incidence function were employed to analyze the impact of different histopathology on prostate cancer-specific mortality(PCSM).Results NEPC group exhibited significantly higher age,serum prostate-specific antigen levels,and NM stages compared to AD group.Additionally,NEPC group had significantly shorter survival times than that in AD group.Prognostic variables included in the analysis showed no multicollinearity.Both univariate and multivariate prognostic analyses,as well as cumulative incidence function analysis,indicated that PCSM risk in NEPC group was significantly higher than that in AD group,both before and after propensity score matching.Conclusion NEPC is an independent poor prognostic factor of PCSM,and clinicians need to perform biopsy in time to confirm the diagnosis and take early treatment measures.关键词
前列腺癌/神经内分泌前列腺癌/预后/SEER数据库Key words
Prostate cancer/Neuroendocrine prostate cancer/Prognosis/SEER database分类
临床医学引用本文复制引用
张鹏,杨明..原发性神经内分泌前列腺癌的临床特征及预后分析[J].中国现代医生,2025,63(12):19-24,52,7.基金项目
宁波市自然科学基金项目(202003N4258) （202003N4258）
