中国现代医生2025，Vol.63Issue(12)：61-64,4.DOI:10.3969/j.issn.1673-9701.2025.12.014
68例成人噬血细胞综合征患者临床特征和预后分析
Analysis on clinical features and prognostic factors in 68 adult hemophagocytic syndrome
张荣耀 1沈艳群 1郭毅刚 1李章志 1张露璐1
作者信息
- 1. 十堰市太和医院 湖北医药学院附属医院血液内科,湖北十堰 442000
- 折叠
摘要
Abstract
Objective To explore the clinical features and prognostic factors of adult hemophagocytic syndrome(HPS).Methods The clinical data of 68 newly diagnosed patients with HPS who were hospitalized from December 2018 to December 2023 were retrospectively analyzed,and clinical features,treatment and prognostic factors of patients were analyzed.Results The median age of 68 patients was 49(17-75)years old,the most common cause was infection,40 cases(58.82％),and the most common clinical manifestation was fever,63 cases(92.6％).Of the 68 patients,12(17.65％)patients died and the median survival time was 32 months.Cox univariate analysis showed that the prognosis of adult HPS was affected by SF,epstein-barr virus(EBV)infection,platelet count(＜20× 109/L),age over 60 years old,activated partial thromboplastin over 60s and other factors(P＜0.05).Multivariate Cox analysis showed that EBV infection and platelet count(＜20×109/L)were independent prognostic factors of adult HPS(P＜0.05).Conclusion The clinical manifestations of adult HPS are not typical,and the prognosis of adult HPS is affected by many factors.EBV infection and platelet count(＜20× 109/L)are independent risk factors for death.关键词
噬血细胞综合征/临床特征/预后Key words
Hemophagocytic syndrome/Clinical features/Prognostic analysis分类
医药卫生引用本文复制引用
张荣耀,沈艳群,郭毅刚,李章志,张露璐..68例成人噬血细胞综合征患者临床特征和预后分析[J].中国现代医生,2025,63(12):61-64,4.
