中西医结合慢性病杂志2025，Vol.2Issue(2)：36-44,9.
药食同源药材在防治精神分裂症的应用及作用机制
Research Progress on the Application and Mechanism of Action of Medicinal and Edible Herbs in the Prevention and Treatment of Schizophrenia
摘要
Abstract
Schizophrenia is a chronic mental disorder that seriously affects patients'thinking,emotions,and behavior.It is widely recognized as one of the difficult to treat mental illnesses due to its long course,recurrent symptoms,and lingering symptoms.Schizophrenia seriously affects the patient's diet,daily life,social interaction,work,and study.In the treatment of clinical schizophrenia,traditional Western medicine has a certain therapeutic effect in improving positive symptoms of patients,but there are limitations in the treatment of negative symptoms and cognitive function,and it is often limited due to significant side effects and high costs.In the face of this situation,people have begun to seek other treatment methods,among which traditional Chinese medicine with the concept of"medicinal food homology"has gradually gained attention.Medicinal and edible herbs,with their natural sources,minimal side effects,and multi-target mechanism of action,provide new ideas for the prevention and treatment of schizophrenia.Under the promotion of the"Healthy China 2030 Plan",the resources of medicinal and edible Chinese medicinal materials have received unprecedented attention.The policy document clearly states that the research and development of traditional Chinese medicine health products will focus on health foods and formula foods with special medical purposes.Medicinal and edible herbs refer to plants or their extracts that can be used as food and have medicinal value.Their advantages lie in convenience,easy availability,and high patient acceptance.This study explores how active ingredients from medicinal and edible herbs,such as ginsenosides,paeonol,schisandrin,icariin,curcumin,etc.,target intracellular phosphatidylinositol kinase/protein kinase B,nuclear transcription factor-κB protein,mitogen activated protein kinase and other signaling pathways through various pharmacological effects such as antioxidant,anti-inflammatory,and promoting nerve regeneration,to provide neuroprotection for patients with schizophrenia and improve symptoms.The research provides new ideas for the prevention of schizophrenia and the development of adjuvant therapy with medicinal and edible herbs.Medicinal and edible herbs have potential in the treatment of schizophrenia,but their safety and specific mechanisms still need further research and verification.Through in-depth research and rational application,new treatment options can be provided for patients with schizophrenia.关键词
精神分裂症/药食同源/活性成分/作用机制Key words
schizophrenia/medicine and food share the same origin/active ingredients/mechanism of action分类
医药卫生引用本文复制引用
殷涛,孙雪莹,曲春成,何伟志,王玉婕,赵永厚..药食同源药材在防治精神分裂症的应用及作用机制[J].中西医结合慢性病杂志,2025,2(2):36-44,9.基金项目
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
