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Microglia and brain macrophages are differentially associated with tumor necrosis in glioblastoma:A link to tumor progression

CHRISTINA LOH YUQI ZHENG ISLAM ALZOUBI KIMBERLEY L.ALEXANDER MAGGIE LEE WEI-DONG CAI YANG SONG KERRIE MCDONALD ANNA K.NOWAK RICHARD B.BANATI MANUEL B.GRAEBER

Oncology Research2025，Vol.33Issue(4)：P.937-950,14.

Oncology Research2025，Vol.33Issue(4)：P.937-950,14.DOI:10.32604/or.2024.056436

Microglia and brain macrophages are differentially associated with tumor necrosis in glioblastoma:A link to tumor progression

CHRISTINA LOH ¹YUQI ZHENG ¹ISLAM ALZOUBI ²KIMBERLEY L.ALEXANDER ³MAGGIE LEE ⁴WEI-DONG CAI ²YANG SONG ⁵KERRIE MCDONALD ⁶ANNA K.NOWAK ⁷RICHARD B.BANATI ⁸MANUEL B.GRAEBER⁹

作者信息

1. Ken Parker Brain Tumor Research Laboratories,Brain and Mind Centre,Faculty of Medicine and Health,The University of Sydney,Sydney,NSW 2050,Australia
2. School of Computer Science,The University of Sydney,Sydney,NSW 2008,Australia
3. Neurosurgery Department,Chris O’Brien Lifehouse,Camperdown,NSW 2050,Australia Department of Neuropathology,Royal Prince Alfred Hospital and Brain and Mind Centre,Faculty of Medicine and Health,The University of Sydney,Sydney,NSW 2006,Australia
4. Department of Neuropathology,Royal Prince Alfred Hospital and Brain and Mind Centre,Faculty of Medicine and Health,The University of Sydney,Sydney,NSW 2006,Australia
5. School of Computer Science and Engineering,University of New South Wales,Sydney,NSW 2052,Australia
6. Brain Cancer Consultancy,Sydney,NSW 2040,Australia
7. Medical School,University of Western Australia,Crawley Campus,Perth,WA 6009,Australia
8. Faculty of Medicine and Health,The University of Sydney,Sydney,NSW 2050,Australia Santuario Accademico S.Giovanni D’Andorno,Casa Alpina‘Principessa Laetitia’,Frazione Bele,Campiglia Cervo,13812,Italy
9. Ken Parker Brain Tumor Research Laboratories,Brain and Mind Centre,Faculty of Medicine and Health,The University of Sydney,Sydney,NSW 2050,Australia Department of Neuropathology,Royal Prince Alfred Hospital and Brain and Mind Centre,Faculty of Medicine and Health,The University of Sydney,Sydney,NSW 2006,Australia University of Sydney Association of Professors(USAP),University of Sydney,Sydney,NSW 2006,Australia
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摘要

关键词

Bone marrow-derived macrophages(BMDM)/CD163/Glioblastoma/glioma stem cells(GSCs)/IBA1/Microglia/Multimodal whole slide analysis/Tumor microenvironment

分类

医药卫生

引用本文复制引用

CHRISTINA LOH,YUQI ZHENG,ISLAM ALZOUBI,KIMBERLEY L.ALEXANDER,MAGGIE LEE,WEI-DONG CAI,YANG SONG,KERRIE MCDONALD,ANNA K.NOWAK,RICHARD B.BANATI,MANUEL B.GRAEBER..Microglia and brain macrophages are differentially associated with tumor necrosis in glioblastoma:A link to tumor progression[J].Oncology Research,2025,33(4):P.937-950,14.

基金项目

funding but aspects of this work(computer analysis)were supported by an Australian Research Council(ARC)grant,DP150104472(MBG) （computer analysis）

The Australian Genomics and Outcomes of Glioma project was funded by a Cancer Council NSW Strategic Research Partnership Grant. （）

Oncology Research

ISSN：0965-0407

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