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Tropism-shifted AAV-PHP.eB-mediated bFGF gene therapy promotes varied neurorestoration after ischemic stroke in mice

Rubing Shi Jing Ye Ze Liu Cheng Wang Shengju Wu Hui Shen Qian Suo Wanlu Li Xiaosong He Zhijun Zhang Yaohui Tang Guo-Yuan Yang Yongting Wang

Neural Regeneration Research2026，Vol.21Issue(2)：P.704-714,11.

Neural Regeneration Research2026，Vol.21Issue(2)：P.704-714,11.DOI:10.4103/NRR.NRR-D-23-01802

Tropism-shifted AAV-PHP.eB-mediated bFGF gene therapy promotes varied neurorestoration after ischemic stroke in mice

Rubing Shi ¹Jing Ye ¹Ze Liu ¹Cheng Wang ¹Shengju Wu ¹Hui Shen ¹Qian Suo ¹Wanlu Li ¹Xiaosong He ²Zhijun Zhang ¹Yaohui Tang ¹Guo-Yuan Yang ¹Yongting Wang¹

作者信息

1. Med-X Research Institute and School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai,China
2. Department of Emergency,the Second Affiliated Hospital,Department of Human Anatomy,School of Basic Science,Guangzhou Medical University,Guangzhou,Guangdong Province,China
折叠

摘要

关键词

AAV-PHP.eB/angiogenesis/basic fibroblast growth factor/gene therapy/ischemic stroke/Ly6A/neurogenesis/neurological function/transient middle cerebral artery occlusion/tropism

分类

医药卫生

引用本文复制引用

Rubing Shi,Jing Ye,Ze Liu,Cheng Wang,Shengju Wu,Hui Shen,Qian Suo,Wanlu Li,Xiaosong He,Zhijun Zhang,Yaohui Tang,Guo-Yuan Yang,Yongting Wang..Tropism-shifted AAV-PHP.eB-mediated bFGF gene therapy promotes varied neurorestoration after ischemic stroke in mice[J].Neural Regeneration Research,2026,21(2):P.704-714,11.

基金项目

supported by the National Natural Science Foundation of China,Nos.81870921(to YW),81974179(to ZZ),82271320(to ZZ),82071284(to YT) （to YW）

National Key R&D Program of China,No.2022YFA1603600(to ZZ),2019YFA0112000(to YT) （to ZZ）

Scientific Research and Innovation Program of Shanghai Education Commission,No.2019-01-07-00-02-E00064(to GYY) （to GYY）

Scientific and Technological Innovation Act Program of Shanghai Science and Technology Commission,No.20JC1411900(to GYY). （to GYY）

Neural Regeneration Research

ISSN：1673-5374

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