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Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease

Qian Yue Shang Li Chon Lok Lei Huaibin Wan Zaijun Zhang Maggie Pui Man Hoi

Neural Regeneration Research2026，Vol.21Issue(2)：P.569-576,8.

Neural Regeneration Research2026，Vol.21Issue(2)：P.569-576,8.DOI:10.4103/NRR.NRR-D-24-00695

Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease

Qian Yue ¹Shang Li ²Chon Lok Lei ³Huaibin Wan ⁴Zaijun Zhang ⁵Maggie Pui Man Hoi⁶

作者信息

1. The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital),Heyuan,Guangdong Province,China Department of Cardiology,The First Affiliated Hospital of Jinan University,Guangzhou,Guangdong Province,China State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao Special Administrative Region,China Department of Pharmaceutical Sciences,Faculty of Health Sciences,University of Macao,Macao Special Administrative Region,China
2. Laboratory for Accelerated Vascular Research,Department of Surgery,University of California San Francisco,San Francisco,CA,USA
3. Department of Biological Sciences,Faculty of Health Sciences,University of Macao,Macao Special Administrative Region,China
4. The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital),Heyuan,Guangdong Province,China
5. State Key Laboratory of Bioactive Molecules and Druggability Assessment,and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases,and Institute of New Drug Research,Jinan University,Guangzhou,Guangdong Province,China Guangdong-Hong Kong-Macao Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research,and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Jinan University College of Pharmacy,Guangzhou,Guangdong Province,China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE),Jinan University College of Pharmacy,Guangzhou,Guangdong Province,China
6. State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao Special Administrative Region,China Department of Pharmaceutical Sciences,Faculty of Health Sciences,University of Macao,Macao Special Administrative Region,China
折叠

摘要

关键词

Alzheimer’s disease/brain microvessel endothelial cells/transcriptomic heterogeneity/endothelial activation/blood-brain barrier impairment/neurovascular cell-cell communication

分类

医药卫生

引用本文复制引用

Qian Yue,Shang Li,Chon Lok Lei,Huaibin Wan,Zaijun Zhang,Maggie Pui Man Hoi..Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease[J].Neural Regeneration Research,2026,21(2):P.569-576,8.

基金项目

supported by the National Natural Science Foundation of China,Nos.82404892(to QY),82061160374(to ZZ) （to QY）

the Science and Technology Development Fund,Macao Special Administrative Region,China,Nos.0023/2020/AFJ,0035/2020/AGJ （）

the University of Macao Research Grant,Nos.MYRG2022-00248-ICMS,MYRG-CRG2022-00010-ICMS(to MPMH) （to MPMH）

the Natural Science Foundation of Guangdong Province,No.2024A1515012818(to ZZ) （to ZZ）

the Fundamental Research Funds for the Central Universities,No.21623114(to ZZ). （to ZZ）

Neural Regeneration Research

ISSN：1673-5374

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