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Single-cell sequencing analysis reveals the essential role of the m^(6)A reader YTHDF1 in retinal visual function by regulating TULP1 and DHX38 translation

Xian-Jun Zhu Xiao-Yan Jiang Wen-Jing Liu Yu-Di Fan Guo Liu Shun Yao Kuan-Xiang Sun Jun-Yao Chen Bo Lei Ye-Ming Yang

Zoological Research2025,Vol.46Issue(2):P.429-445,17.
Zoological Research2025,Vol.46Issue(2):P.429-445,17.DOI:10.24272/j.issn.2095-8137.2024.399

Single-cell sequencing analysis reveals the essential role of the m^(6)A reader YTHDF1 in retinal visual function by regulating TULP1 and DHX38 translation

Xian-Jun Zhu 1Xiao-Yan Jiang 2Wen-Jing Liu 2Yu-Di Fan 2Guo Liu 3Shun Yao 4Kuan-Xiang Sun 2Jun-Yao Chen 2Bo Lei 4Ye-Ming Yang5

作者信息

  • 1. Henan Branch of National Clinical Research Center for Ocular Diseases,Henan Eye Hospital,People’s Hospital of Zhengzhou University,Henan Provincial People’s Hospital,Zhengzhou,Henan 450003,China Sichuan Provincial Key Laboratory for Human Disease Gene Study,Center for Medical Genetics,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China Sichuan-Chongqing Joint Key Laboratory for Pathology and Laboratory Medicine,Jinfeng Laboratory,Chongqing 400039,China Qinghai Key Laboratory of Qinghai Tibet Plateau Biological Resources,Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine Research,Northwest Institute of Plateau Biology,Xining,Qinghai 810008,China
  • 2. Sichuan Provincial Key Laboratory for Human Disease Gene Study,Center for Medical Genetics,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China
  • 3. Sichuan Provincial Key Laboratory for Human Disease Gene Study,Center for Medical Genetics,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China Sichuan-Chongqing Joint Key Laboratory for Pathology and Laboratory Medicine,Jinfeng Laboratory,Chongqing 400039,China
  • 4. Henan Branch of National Clinical Research Center for Ocular Diseases,Henan Eye Hospital,People’s Hospital of Zhengzhou University,Henan Provincial People’s Hospital,Zhengzhou,Henan 450003,China Eye Institute,Henan Academy of Innovations in Medical Science,Zhengzhou,Henan 451162,China
  • 5. Sichuan Provincial Key Laboratory for Human Disease Gene Study,Center for Medical Genetics,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China Qinghai Key Laboratory of Qinghai Tibet Plateau Biological Resources,Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine Research,Northwest Institute of Plateau Biology,Xining,Qinghai 810008,China
  • 折叠

摘要

关键词

Epitranscriptomics/N6-methyladenosine(m^(6)A)/Inherited retinal dystrophies(IRDs)/YTHDF1/Single-cell RNA sequencing/Photoreceptor degeneration

分类

医药卫生

引用本文复制引用

Xian-Jun Zhu,Xiao-Yan Jiang,Wen-Jing Liu,Yu-Di Fan,Guo Liu,Shun Yao,Kuan-Xiang Sun,Jun-Yao Chen,Bo Lei,Ye-Ming Yang..Single-cell sequencing analysis reveals the essential role of the m^(6)A reader YTHDF1 in retinal visual function by regulating TULP1 and DHX38 translation[J].Zoological Research,2025,46(2):P.429-445,17.

基金项目

supported by the National Natural Science Foundation of China(82371083,82471100,82121003,82271084) (82371083,82471100,82121003,82271084)

Program of Science and Technology International Cooperation Project of Qinghai province(China)(2022-HZ-814)。 (China)

Zoological Research

2095-8137

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