长春中医药大学学报2025，Vol.41Issue(5)：586-590,5.DOI:10.13463/j.cnki.cczyy.2025.05.024
糖尿病肾脏疾病足细胞自噬机制及中药干预研究进展
Research progress in the mechanism of podocyte autophagy and intervention of traditional Chinese medicine in diabetic kidney disease
摘要
Abstract
Diabetic kidney disease(DKD)is one of the microvascular complications of diabetes,with high incidence and complex pathogenesis.Podocyte autophagy is closely related to the disease,mainly through the mediation of three classical signal pathways of mTOR,AMPK,SIRT3 to improve the state of the disease.Traditional Chinese medicine can change the related markers of podocyte autophagy,such as LC3,p62 and Beclin-1,and affect the relevant signal pathways,indicating that the mechanism of podocyte autophagy can be used as the mechanism of traditional Chinese medicine in the intervention of DKD.This provides the certain scientific research and application value for the intervention of traditional Chinese medicine in podocyte autophagy of this disease.关键词
糖尿病肾脏疾病/足细胞自噬/作用机制/中医药/研究进展Key words
diabetic kidney disease/podocyte autophagy/mechanism of action/traditional Chinese medicine/research progress分类
医药卫生引用本文复制引用
刘世林,李安冬,南征,孙健..糖尿病肾脏疾病足细胞自噬机制及中药干预研究进展[J].长春中医药大学学报,2025,41(5):586-590,5.基金项目
吉林省中医药科技项目(2024073) （2024073）
吉林省教育厅科学技术研究项目(JJKH20241050KJ) （JJKH20241050KJ）
