大学化学2025，Vol.40Issue(4)：239-244,6.DOI:10.12461/PKU.DXHX202406090
铜催化Kharasch-Sosnovsky型反应构筑碳氧键
Copper-Catalyzed C―O Bond Formation by Kharasch-Sosnovsky-Type Reaction
摘要
Abstract
Transition metal-catalyzed carbon-heteroatom bond formation is a crucial area in synthetic organic chemistry.The Kharasch-Sosnovsky reaction,catalyzed by copper,facilitates the conversion of olefins to allylic esters using tert-butyl peroxybenzoate as both an oxidant and oxygen source.In line with the"National Dual-Carbon Strategy",the development of green and efficient catalytic systems for carbon-based transformations has become a key focus in organic chemistry.In this context,the Kharasch-Sosnovsky-type reaction has witnesses notable advances regarding asymmetric versions,ligand design,substrate scope expansion,and sustainable conditions.By surveying the cutting-edge chemical research,this paper presents a concise overview of the discovery and new progress of Kharasch-Sosnovsky reaction.It is hoped that this review can not only enhance students'comprehension of fundamental organic chemistry concepts,but also effectively fill the gaps in existing textbooks,achieving a deep integration of basic chemical knowledge with cutting-edge research in the discipline.关键词
Kharasch-Sosnovsky反应/铜催化/烯烃氧化/不对称自由基反应Key words
Kharasch-Sosnovsky reaction/Copper catalysis/Olefin oxidation/Asymmetric radical reaction分类
社会科学引用本文复制引用
王芃梓,肖文精,陈加荣..铜催化Kharasch-Sosnovsky型反应构筑碳氧键[J].大学化学,2025,40(4):239-244,6.基金项目
国家自然科学基金面上项目(22171099) （22171099）
