大学化学2025，Vol.40Issue(4)：322-325,4.DOI:10.12461/PKU.DXHX202406016
车间一杯酒,中枢两行泪——都是双硫仑样反应惹的祸
One Drink,Two Tears in the Central Nervous System:The Perils of Disulfiram-Like Reactions
摘要
Abstract
In the"human body"factory,the director of the hepatocyte workshop,nicknamed"Xiaodeng",manages ethanol metabolism to maintain stability.However,with the onset of diseases like diabetes and insomnia,the central nervous system introduces foreign aids such as sedatives and antihypertensive drugs.Xiaodeng inadvertently overlooks the potential disulfiram-like reaction between medications and aldehyde dehydrogenase.In an unfortunate incident,a conflict between cephalosporin drugs and ethanol metabolism inhibits acetaldehyde dehydrogenase,leading to acetaldehyde accumulation and ensuing chaos.Recognizing the oversight,Xiaodeng strengthens safety measures and instructs workers to exercise caution when using medications.Although the crisis is contained,this experience underscores the hepatocytes'enhanced sense of responsibility and mission.We should learn from this and prioritize life,avoiding unnecessary risks such as excessive alcohol consumption.Let us unite in safeguarding this miraculous factory to ensure its safety and prosperity.关键词
双硫仑样反应/酒精代谢/药物与酒精互作Key words
Disulfiram-like reaction/Alcohol metabolism/Drug-alcohol interactions分类
社会科学引用本文复制引用
梁一铭,潘籽言,陈建成..车间一杯酒,中枢两行泪——都是双硫仑样反应惹的祸[J].大学化学,2025,40(4):322-325,4.基金项目
南京大学百位名师邀约项目 （）
南京大学国际化课程建设项目 （）
南京大学短期国外专家项目 （）
