大学化学2025，Vol.40Issue(4)：326-330,5.DOI:10.12461/PKU.DXHX202406038
华法林:从毒药到良方
Warfarin:From Poison to Cure,the Remarkable Journey of a Molecule
摘要
Abstract
Originating from moldy sweet clover and developed in a biochemical laboratory,warfarin was initially deployed as a potent rodenticide.However,its journey into the medical field was met with skepticism and opposition,largely due to its reputation as a poison and circulating rumors.Scientists eventually uncovered warfarin's anticoagulant mechanism and demonstrated the benefits of its use in anticoagulation therapy for patients.Since then,warfarin and its derivatives have become key agents in both anticoagulant treatment and rodent control.关键词
抗凝药物/双香豆素/维生素K/维生素K环氧化物还原酶Key words
Anticoagulant/Dicoumarol/Vitamin K/Vitamin K epoxide reductase分类
社会科学引用本文复制引用
方洲,张致豪,蒋炜涵,陈建成..华法林:从毒药到良方[J].大学化学,2025,40(4):326-330,5.基金项目
南京大学百位名师邀约项目 （）
南京大学国际化课程建设项目 （）
南京大学聘请短期国外专家项目 （）
