大学化学2025，Vol.40Issue(4)：359-366,8.DOI:10.12461/PKU.DXHX202406107
N-酰基磺酰胺的电化学去芳香螺环化创新实验
Innovative Experiment of Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides
摘要
Abstract
Spiro compounds are of great interest in drug design and organic synthesis due to their unique three-dimensional structures and biological activities.Traditional methods for synthesizing spiro compounds often involve the use of stoichiometric oxidants,which can be harsh and complicated.In this experiment,dearomative spirocyclization of N-acyl sulfonamides is achieved efficiently and in an environmentally friendly manner through electrochemical oxidation.During the experimental course,students will learn the fundamental principles of electrochemical synthesis,acquire operational skills,and gain an understanding of the synthetic mechanisms involved in electrochemical dearomative spirocyclization.By guiding students to explore the experimental mechanisms and integrating theoretical knowledge with practical application,this approach enhances their experimental skills and scientific inquiry abilities while fostering an appreciation for green chemistry and sustainable synthesis methods.关键词
电化学合成/N-酰基磺酰胺/去芳香螺环化/实验教学Key words
Electrochemical synthesis/N-Acyl sulfonamides/Dearomative spirocyclization/Experiment teaching分类
社会科学引用本文复制引用
林彩霞,刘婷,施兆江,晏宏,叶克印,袁耀锋..N-酰基磺酰胺的电化学去芳香螺环化创新实验[J].大学化学,2025,40(4):359-366,8.基金项目
教育部2022年度基础学科拔尖计划2.0研究课题(20222114) （20222114）
福州大学研究生教育教学改革精品课程建设项目(0480-00489503) （0480-00489503）
