南方医科大学学报2025，Vol.45Issue(5)：995-1002,8.DOI:10.12122/j.issn.1673-4254.2025.05.12
慢性乙型肝炎病毒感染影响孕妇妊娠中晚期及产后健康相关生活质量:一项前瞻性队列研究
Chronic HBV infection affects health-related quality of life in pregnant women in the second and third trimesters and postpartum period:a prospective cohort study
摘要
Abstract
Objective To evaluate the impact of HBV infection on pre-and postpartum health-related quality of life(HRQoL)in pregnant women.Methods A prospective matched cohort consisting of 70 HBV-infected and 70 healthy pregnant women was recruited from the Fifth Affiliated Hospital of Guangzhou Medical University between April 17 and September 25,2023.HRQoL of the participants was assessed at 16-24 weeks of gestation,between 32 weeks and delivery,and 5-13 weeks postpartum.Mixed linear models were used for evaluating temporal trends of HRQoL changes,and univariate ANOVA with multiple linear regression was used to identify the predictors of HRQoL.Results Compared with healthy pregnant women,HBV-infected pregnant women had consistently lower total HRQoL scores across all the 3 intervals,with the lowest scores observed between 32 weeks of gestation and delivery,during which these women had significantly reduced mental component scores(74.27±13.43 vs 80.21±12.9,P=0.009)and postpartum mental(76.52±16.19 vs 85.02±6.51,P<0.001)and physical component scale scores(77.17±14.71 vs 83.09±10.1,P=0.009).HBV infection was identified as an independent risk factor affecting HRQoL during late pregnancy and postpartum periods.Additional independent risk factors for postpartum HRQoL reduction included self-pay medical expenses,spouse's neutral attitude toward the current pregnancy,and preexisting comorbidities(all P<0.05).Conclusion HRQoL of pregnant women deteriorates progressively in late pregnancy,and HBV infection exacerbates reductions of physical function and role emotion in late pregnancy and after delivery,suggesting the importance of targeted interventions for financial burdens,partner support and comorbid conditions to improve HRQoL of pregnant women with HBV infection.关键词
慢性乙型肝炎/孕妇/生活质量Key words
chronic hepatitis B/pregnant women/quality of life引用本文复制引用
邓悦滢,耿雅雯,彭婷婷,丘峻朝,何丽娟,谢丹,陈姿任,欧阳石,阎升光..慢性乙型肝炎病毒感染影响孕妇妊娠中晚期及产后健康相关生活质量:一项前瞻性队列研究[J].南方医科大学学报,2025,45(5):995-1002,8.基金项目
河北省卫健委项目 快速康复护理降低公共卫生事件期间住院患者焦虑作用研究(No.20211885)中国科技部"一带一路"外国专家创新人才交流项目(G2022030048L) （No.20211885）
