广东医学2025，Vol.46Issue(4)：592-597,6.DOI:10.13820/j.cnki.gdyx.20243203
变应性鼻炎患儿血清miR-142、miR-181a水平及对临床疗效的预测价值
Serum miR-142 and miR-181a levels and their predictive value for clinical efficacy in children with allergic rhi-nitis
摘要
Abstract
Objective To explore the levels of serum microRNA-142(miR-142)and microRNA-181a(miR-181a)in children with allergic rhinitis(AR)and their predictive value for clinical efficacy.Provide help for clin-ical treatment.Methods A retrospective analysis was conducted on 179 children with AR admitted to our hospital be-tween January 2021 and December 2022.Based on the clinical efficacy of sublingual specific immunotherapy(SLIT)after 3 months,patients were divided into the effective group(n=127)and the ineffective group(n=52).The correlation be-tween serum miR-142,miR-181a levels and helper T cells 17(Th17),regulatory T cells(Treg),and Th17/Treg ra-tio was analyzed using Pearson correlation.Multivariate logistic regression was used to analyze factors influencing clinical efficacy in AR children.Receiver operating characteristic(ROC)curves were used to evaluate the predictive value of ser-um miR-142 and miR-181a levels for clinical efficacy in AR children.Results Compared with the effective group,the ineffective group showed significantly higher levels of Th17,Th17/Treg ratio,and miR-142(t=4.700,12.810,9.956;P＜0.05)and significantly lower levels of Treg and miR-181a(t=7.529,10.644;P＜0.05).Serum miR-142 levels in AR children were positively correlated with Th17 and Th17/Treg ratio(r=0.468,0.523;P＜0.05)and negatively correlated with Treg(r=-0.547;P＜0.05).Serum miR-181a levels were negatively correlated with Th17 and Th17/Treg ratio(r=-0.516,-0.498;P＜0.05)and positively correlated with Treg(r=0.562;P＜0.05).Multivariate logistic regression revealed that miR-142(OR=1.338),Th17(OR=1.314),and Th17/Treg ratio(OR=1.358)were independent risk factors for clinical efficacy in AR children(P＜0.05),while miR-181a(OR=0.706)and Treg(OR=0.741)were protective factors(P＜0.05).The ROC analysis showed that the area under the curve(AUC)for the combined prediction of clinical efficacy using serum miR-142 and miR-181a levels was 0.894,which was significantly greater than the AUC for miR-142 alone(Z=3.144,P=0.002)or miR-181a alone(Z=2.341,P=0.019).Conclusion Serum miR-142 and miR-181a levels in AR children may be related to immune balance,and their combination has high predictive value for clinical efficacy.关键词
变应性鼻炎/微小RNA-142/微小RNA-181aKey words
allergic rhinitis/microRNA-142/microRNA-181a分类
医药卫生引用本文复制引用
曲莉,尹昕,张蕊,杨妍,裴明阳..变应性鼻炎患儿血清miR-142、miR-181a水平及对临床疗效的预测价值[J].广东医学,2025,46(4):592-597,6.基金项目
河南省医学科技攻关联合共建项目(LHGJ202204019) （LHGJ202204019）
