广东医学2025，Vol.46Issue(4)：611-614,4.DOI:10.13820/j.cnki.gdyx.20243282
卵巢癌患者血清中腓骨蛋白1的水平及临床诊断价值
Serum fibulin-1 levels and their diagnostic value in ovarian cancer patients
摘要
Abstract
Objective To investigate the expression level of serum fibulin-1(FBLN-1)in ovarian cancer and evaluate its clinical diagnostic significance.Methods Between July 2023 and June 2024,83 ovarian cancer patients confirmed by postoperative pathology(ovarian cancer group),70 patients with benign ovarian tumors(benign group),and 90 healthy women undergoing routine health examinations(control group)were enrolled at Lianyungang Municipal Dongfang Hospital.Serum levels of FBLN-1,cancer antigen 125(CA125),and human epididymis protein 4(HE4)were measured using enzyme-linked immunosorbent assay(ELISA)and chemiluminescence methods.Receiver operating characteristic(ROC)curve analysis was performed to assess the diagnostic performance of FBLN-1,CA125,and HE4 individually as well as in combination.Results The ovarian cancer group exhibited significantly higher serum FBLN-1 levels[(30.51±6.12)ng/mL]compared to the benign group[(12.85±5.55)ng/mL]and the control group[(16.09±5.62)ng/mL](P＜0.001).In addition,patients with stage Ⅲ and Ⅳ ovarian cancer had significantly high-er serum levels of FBLN-1,CA125,and HE4 than those with stage Ⅰ and Ⅱ disease(P＜0.001).The combined de-tection of FBLN-1,CA125,and HE4 yielded an area under the ROC curve(AUC)of 0.917,which was superior to the AUC for FBLN-1(0.879),CA125(0.790),and HE4(0.826)when used alone.Conclusion Serum FBLN-1 lev-els are significantly elevated in ovarian cancer patients and correlate with disease progression.The combined measurement of FBLN-1,CA125,and HE4 demonstrates high potential as an auxiliary diagnostic tool for ovarian cancer.关键词
卵巢癌/血清腓骨蛋白1/糖类抗原125/人附睾蛋白4/联合检测/诊断Key words
ovarian cancer/serum fibulin-1/cancer antigen 125/human epididymis protein 4/combined de-tection/diagnosis分类
医药卫生引用本文复制引用
王永琪,薄维波,陈守庆,陈霞..卵巢癌患者血清中腓骨蛋白1的水平及临床诊断价值[J].广东医学,2025,46(4):611-614,4.基金项目
连云港市卫生科技项目指导性课题(ZD202305) （ZD202305）
